摘要
目的 研究人类白细胞Ⅱ类抗原 (HLA DR)基因相容对肾移植长期存活的影响。方法 采用基因分型技术 ,回顾性分析 5 18例首次肾移植HLA DR基因相容情况。结果 单个移植中心达到基因水平DR相配的受者超过 10 % ,半数以上可达 1个DR相配。HLA DR相容的受者急性排斥反应显著减少、早期肾功能恢复顺利 ,1～ 5年人存活率提高 10 %～ 2 1.7% (P <0 .0 5 )、肾存活率提高 17%～ 37.7% (P <0 .0 1) ,差异有显著性。Cox模型独立分析表明 ,DR错配是影响移植肾长期存活的主要因素之一。结论 选择基因水平HLA DR相容具有临床可行性、对首次尸肾移植长期存活具有显著影响。
Objective To study the effect of genomic HLA DR compatibility on long term survival in renal transplantation.Methods A retrospective study was performed on 518 first cadaver renal transplants by using genotyping technique.Results More than 10% recipients shared HLA DR matching at DNA level, half of 1 DR mismatches. The recipients with HLA DR matched transplants showed a significant decrease of acute rejection episodes and a smooth recovery of early renal function as compared with those of DR mismatching kidneys. The 1 to 5 year person survival rate was increased by 17% to 37.7% ( P <0.01) respectively.Multivariate analysis of 10 variables by Cox regression model revealed that DR mismatching was the most important factors influencing the long term graft survival.Conclusion Genomic HLA DR compatibility had a significant impact on long term survival of first cadaver kidney transplantation.
出处
《中华器官移植杂志》
CAS
CSCD
2000年第2期109-111,共3页
Chinese Journal of Organ Transplantation
基金
国家卫生部科研基金!96 2 2 89
