摘要
采用 EL ISA方法检测旋毛虫病患者血清中各类特异性抗体 ,结果表明 :特异性抗体检出率依次是 Ig G、Ig E、Ig D、Ig A和 Ig M,其中全部病人血清中均有特异性 Ig G,90 .0 %的病人检出特异性 Ig E,86 .6 7%的病人检出特异性 Ig D;Ig G是旋毛虫感染免疫中最具保护作用的抗体 ,检出率高且半衰期长 ,故首选特异性 Ig G作为免疫诊断的指标 ;特异性 Ig E在旋毛虫感染中能介导保护性免疫 ,并能介导速发型超敏反应引起免疫病理损伤 ,Ig E是旋毛虫等蠕虫感染免疫中值得注意的免疫球蛋白 ;本实验中观察到血清特异性 Ig D检出率较高 ,但 Ig D确切的免疫机理尚不清楚。提示应根据不同的目的 ,检测不同类型的特异性抗体。对血清各类抗体的检测 ,可反映机体感染旋毛虫后的免疫状态。
The each class specific antibodies from the trichinosis patients serum was examined by ELISA method. The results showed that the positive rate of specific antibody was IgG, IgE, IgD, IgA, IgM in order. All patients had specific IgG Ab, 90.0% patients had specific IgE, 86.67% patients had specific IgD. Because IgG was the most protective antibody in the infective immunity of T. spiralis and the detection rate of lgG was the highest and the halflife of IgG was long, specific lgG was the first choice as the index of immunodiagnosis. In T. spiralis infection, specific IgE could mediate protective immunity and induce immediate hypersensitivity resulting in immunopathological injury. IgE was a noticeable antibody in T. spiralis infection. The detection rate of specific IgD was high although its immune mechanism was still unclear. This suggested that different class antibodies were determined according to different aim in T. spiralis infection. The examination for each class antibodies may indicate the immune condition of host and the immune effect of vaccine after T.spiralis infection.
出处
《地方病通报》
2000年第1期22-24,共3页
Endemic Diseases Bulletin
