摘要
建立绵羊感染细粒棘球蚴 (Echinococcusgranulosus,E.g)疾病模型 ,应用于包虫病的防治研究。将羊源 E.g原头节经腹腔及颈内静脉接种 2 4只绵羊 ,依据感染率、囊肿体积与分布等指标 ,建立绵羊感染 E.g疾病模型。结果显示感染率为 91.6 % ,囊肿平均体积 (13.92± 2 .5 3) cm3。多数囊肿分布于腹腔或附着于腹壁、肠系膜、大网膜等 ,部分侵入肝脏和肺脏。本模型制备方法简单 ,感染率高 ,对包虫病的防治研究具有重要的实用价值。
For prevention and treatment of Echinococcus infection, establishment of sheep model has been tried by infection of Echinococcus granulosus(E.g)protoscoleces. E.g protoscolecs collected from infected sheep in abattoir were injected peritoneally and intravenously into 24 health sheep. After six months,all the sheep were sacrificed and examined for the infection rate,cyst volume and distribution in the organs. E.g infection rate was 91.6% in sheep. The average volume of the cysts in sheep with 13.92± 2.53 cm 3,most of the cysts located in abdominal cavity,abdominal wall,mesentery and great epiploon etc,some of the cysts was invaded in lung and liver. Sheep models for Echinococcus granulosus can be established with peritoneal and intravenous injection of the protoscoleces by which it may cause better morphological evidence and higher infected rates and more useful purposes in comparison with small animals(mice or gerbils).
出处
《地方病通报》
2000年第1期15-16,共2页
Endemic Diseases Bulletin
基金
国家自然科学基金!(39860 0 78)
关键词
细粒棘球蚴病
绵羊
动物模型
Echinococcus granulosus
Sheep
Animal model
