摘要
肿瘤的免疫治疗是治疗肿瘤的新方法 ,它通过增强肿瘤抗原或肿瘤相关抗原的免疫原性 ,诱导机体产生肿瘤特异性的免疫应答反应而杀伤肿瘤细胞。本系列研究采用同源重组方法构建了表达人癌胚抗原 (carcinoembryonicantigen ,CEA)的重组痘苗病毒 ,经动物实验证明了其具有强免疫原性、安全性和防治CEA阳性肿瘤的可靠性。
Immunotherapy is a new method to treat tumors. In this method, the tumor cells were killed by means of improving the immunogenicity of tumor antigens or tumor associated antigens and inducing tumor specific cell mediated immune response. In this series studies, the carcino embryonic antigen (CEA) recombinant vaccinia virus was constructed by homologous recombination, and its strong immunogenicity, safety and reliability of treatment and prevention on CEA positive tumors were proved in animal experiments.
出处
《中山医科大学学报》
CSCD
2000年第2期81-83,共3页
Academic Journal of Sun Yat-sen University of Medical Sciences
基金
广东省医药卫生"九.五
五个一工程"项目
广州市科委资助!( 98-J-0 18-0 1)
关键词
痘苗病毒
癌胚抗原
免疫疗法
CEA阳性肿瘤
vaccinia virus
carcinoembryonic antigen
CEA positive tumor
immunotherapy
