摘要
目的：观察当归注射液对慢性阻塞性肺疾病（ＣＯＰＤ）伴肺功能高压患者血流动力学、血管收缩肽肺功能和动脉血气的影响。方法：将６０例ＣＯＰＤ伴肺动脉高压患者随机分成治疗组和对照组。每组３０例，分别静脉滴注２５％当归注射液和５％葡萄糖注射液，１０天为１个疗程，观察用药前后血流动力学、血浆内皮素．１（ＥＴ－１）、血管紧张素Ⅱ（ＡＴ－Ⅱ）、内源性洋地黄物质（ＥＤＦ）、肺功能和动脉血气的变化。结果：静脉滴注２５％当归注射液后患者平均肺动脉压（ｍＰＡＰ）和肺血管阻力（ＰＶＲ）分别降低（１８±５）％和（２７±８）％（Ｐ＜０．０５，Ｐ＜０．０１），血浆ＥＴ－１、ＡＴ－Ⅱ和ＥＤＦ分别降低（２０±６）％和（３６±９）％和（３８±１１）％（Ｐ＜０．０５，Ｐ＜０．０１），动脉血氧分压升高（Ｐ＜０．０１）。而对照组患者上述各指标无明显变化。两组患者肺功能无明显改变。结论：当归注射液通过影响血管收缩肽的代谢而改善肺血流，同时提高机体的氧浓度。
To study the effects of 25% Angelica sinensis injection on hemodynamics, endothelin-1 (ET1 ), angiotensin- Ⅱ (AT-Ⅱ), endogenous digitalis-like factor (EDF), pulmonary function and arterial blood gas in the patients with chronic obstructive pulmonary disease (COPD) complicated pulmonary hypertension. Methods: Sixty COPD patients complicated with pulmonary hypertension in remission stage were randomly divided into two groups, 30 cases in each. The Angelica group and the control group were treated with Angelica sinensis injection and 5% glucose injection (250ml, intravenous dripping per day for 10 days) respectively. It was designed to investigate the changes of hemodynamics, ET-1, AT-Ⅱ, EDF, pulmonary function and arterial blood gas. Results: The levels of mean pulmonary arterial pressure (mPAP), pulmonary vascular resistance (PVR), blood ET-1, AT-Ⅱand EDF were reduced by (18±5) %, (27±8) %, (20±6) %, (36±9) %, (38±11) % respectively, and PaO2 was increased in Angelica group (P ＜ 0. 05 or P < 0. 01 ). There were insignificant differences of the above parameters in the control group, and no changes of pulmonary function in both groups. Conclusion: Twenty-five Percent of Angelica injection can improve pulmonary hemodynamics through influencing the metabolism of ET-1, AT-Ⅱand EDF as well as increase PaO2 of the body.
出处
《中国中西医结合杂志》
CSCD
北大核心
2000年第3期187-189,共3页
Chinese Journal of Integrated Traditional and Western Medicine
