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JAK2/STAT途径在生长激素信号传递中的作用 被引量：2

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摘要 生长激素 (GH)信号传递的机制尚不十分清楚。近年发现JAK2 /STAT途径可能在其信号传递中起着重要的作用 :即GH与生长激素受体 (GHR)结合后首先活化JAK2 ,然后在JAK2和GHR的共同作用下 ,活化STAT ,最后STAT转移到细胞核内 ,与其调节基因的启动子内的特殊序列结合 ,从而激活基因的转录 ,本文就JAK2 /STAT途径的活化机制、激活基因转录的机理及此途径的调节和关闭进行了阐述。
作者 栾好江 邓洁英
机构地区 中国医学科学院
出处 《国外医学（内分泌学分册）》 2000年第2期88-91,共4页 Foreign Medical Sciences(Section of Endocrinology)
关键词 生长激素 JAK2 STAT 信号传递
分类号 R335 [医药卫生—人体生理学]
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参考文献10

  • 1Rui L,Mathews LS,Hotta K,et al.Identification of SH2-beta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling〔J〕[].Molecular and Cellular Biology.1997
  • 2Johnson HM,Torres BA,Green MM,et al.Cytokine-receptor complexes as chaperones for nuclear translocation of signal transducers〔J〕[].Biochemical and Biophysical Research Communications.1998
  • 3Teglund S,Mckay C,Schuetz E,et al.STAT5a and STAT5b proteins have essential and nonessential, or rebundent, roles in cytokine responses〔J〕[].Cell.1998
  • 4Vinkemeier U,Moarefi I,Darnell JE,et al.Structure of the amino-terminal protein interaction domain of STAT-4〔J〕[].Science.1998
  • 5Sasse J,Hemmann U,Schwartz C,et al.Mutational analysis of acute-phase response factor/STAT3 activation and dimerization〔J〕[].Molecular and Cellular Biology.1997
  • 6Ali S.Prolactin receptor regulates STAT5 tyrosine phosphorylation and nuclear translocation by two separate pathways〔J〕[].Journal of Biological Chemistry.1998
  • 7Gebert CA,Park SH,Waxman DJ.Regulation of signal transducer and activator of transcription (STAT) 5b activation by the temporal pattern of growth hormone stimulation〔J〕[].Journal of Molecular Endocrinology.1997
  • 8Pircher TJ,Flores-Morales A,Mui AL,et al.Mitogen-activated protein kinase inhibition decreases growth hormone stimulated transcription mediated by STAT5〔J〕[].Molecular and Cellular Endocrinology.1997
  • 9Minamoto S,Ikegamek,Ueno K,et al.Cloning and functional analysis of new members of STAT induced STAT inhibitor(SSI) family: SSI-2 and SSI-3〔J〕[].Biochemical and Biophysical Research Communications.1997
  • 10Ram PA,Waxman DJ.Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP1 and nuclear JAK2 tyrosine kinase〔J〕[].Journal of Biological Chemistry.1997

同被引文献38

  • 1杜健,张庆茹,史书军,倪耀娣,张洪德,郭红斌.增乳保康散对奶牛泌乳内分泌的影响[J].中国兽医杂志,2007,43(3):37-38. 被引量：5
  • 2方福德.分子生物学前沿技术[M].北京:北京医科大学中国协和医科大学联合出版社,1997.34.
  • 3成军 主编.肿瘤相关基因[M].北京：北京医科大学出版社,1999.96-100.
  • 4Boke-Feysit C,Goffin V,Edery M et al. Prolactin and its recePtor:actives,signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr.Rev., 1998,19 : 225 -268
  • 5Kirken R A,Malabarba M G,xu et al. Prolactin signaling in mammary gland development. J. Biol. Chem.,1997,12:7567- 7569
  • 6Yu-lee L Y Luo G,Book M L et al. Lactogenic hormone signal transduction.Biol. ReProd., 1998,58:295-301
  • 7Tseng L&Zhu HHAD :Progestin, estrogen,and insulin-like growth factor-Ⅰ stimulate theprolactin recptor mRNA In human endometrialstrmoal cells.J Soc Gynecol Investig, 1998(3) : 149
  • 8Tadokoro N,Koibuchi N,Ohtake H, Kawatsu T,Kato Y,Yamsoka S&Kumasaka T, Expression of prolactin gene in human decidua during pregnancy studied by in situ hybridizstion histochemistry.Endocr, 1995 (4) :537
  • 9Rreeman ME,Kanyicska B,Lerant A,et al..Physiol Rev,2000(4):1523-1631
  • 10Goffin V,Bouchard B,Ormandy CJ.et al.. Ann-N-Y-Acad-Sci,1998(1) :498-509

引证文献2

二级引证文献28

国外医学（内分泌学分册）
2000年 第2期

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