摘要
目的 :探讨转化生长因子β1(TGF - β1)与原发性肝癌(PHC)发生发展的关系。方法 :采用TGF - β1 多克隆抗体对29例人原发性肝癌组织进行ABC免疫组化标记 ,并做半定量分析。结果 :在25例肝细胞肝癌中TGF - β1表达显著高于正常肝组织及癌旁组织。高危转移组患者其表达明显高于低危转移组。TGF - β1 表达与肝细胞损伤血清学指标GPT及γ -GT有相关关系。结论 :TGF - β1 与肝细胞肝癌的发生发展密切相关 ,TGF - β1 水平增高可增加肝细胞肝癌的转移危险性。
Objective: To study the relationship between TGF-β1 and the genesis and development of primary hepatocarcinoma(PHC) Methods:ABC immunohistochemical staining with a polyclonal antibody against TGF-β1 was used in 29 cases of PHC Results: In 25 cases of human hepatocellular carcinoma (HCC) ,the expression of TGF-β1 increased remarkably The level of TGF-β1 was much higher in the patients with high risk of metastasis The expression of TGF-β1 showed a significant correlation with serum GPT and Y-GT Conclusion: TGF-β1 is closely related with the genesis and development of HCC The higher level of TGF-β1 probably can increase the risk of tumor metastasis
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2000年第2期93-95,共3页
Chinese Journal of Clinical Oncology
关键词
转化生长因子
肝细胞癌
肝肿瘤
TGFΒ1
Transforming growth factor-β_1 Hepatocellular carcinoma Immunohistochemistry
