摘要
目的 比较明竹欣(Valacicolvir)综合疗法和阿昔洛韦(ACV)片剂及针剂联合激光治疗复发性尖锐湿疣的疗效和安全性。方法 将符合入选标准的150例复发性尖锐湿疣患者按其自愿随机分组,“明竹欣”组:口服“明竹欣”300mg,每天2次,共服14天;ACV片剂组:口服ACV200mg,每天5次,共服14天;ACV针组:静脉滴注ACV5mg/kg,每天3次,共7天。在服药疗程中段应用激光机清除所有病灶。激光治疗后第3、7、10、14天按PASI评分法进行评价,治疗结束后3个月及6个月各随访1次,记录复发情况。通过观察不良反应及治疗前后血尿常规、肝肾功能评价其安全性。结果 “明竹欣”组疗效与ACV针组相近(P>0.05),且明显高于ACV片剂组(P<0.01)。在总复发率方面,“明竹欣”组(0％)与ACV针组(4％)相近,而与ACV片剂组(33.33％)有显著差异(P<0.01)。结论 “明竹欣”综合疗法治疗复发性尖锐湿疣的疗效明显优于ACV片,不良反应少,服药更方便,患者依从性更好。“明竹欣”综合疗法是治疗复发性尖锐湿疣的安全有效方法。
To compare the effectiveness and safety of three drugs, MAXVIR(Valaciclovir hydrochloride), acyclovir tablet( ACV) Tab and acyclovir ingection (ACV Inj) in the treatment of recurrent condyloma acuminatum (RCA). Methods One hundred and fifty patients with RCA were randomized and divided into three groups. The patients in group MAXVIR(group A) took 0.3g MAXVIR orally twice a day for 14 days, ones in group ACV Tab(group B) took 0.2g acyclovir tablet orally five times a day for 14 days, and ones in group ACV Inj(group C) were injected acyclovir, 5 mg per kilogram iv drip three times a day for 7 days. During the period of treatment, every patient got an operation to erase the warts by laser, then, PASI score method was employed to evaluate their treatment effectiveness on the third, seventh, tenth, fourteenth day after the operation, and finally they were followed up at the ends of the third and the sixth month after the treatment and the recurrence rates were also recorded. The safeties of the three therapies were assessed according to the routine blood and urine tests and the function of the kidneys and levers of the patients. Results The effectiveness of group A and C was almost similar, which was much higher than that of group B(P<0.01). The recurrence rates of RCA in group A, C and B were 0.00%, 4.00% and 33. 33%, respectively, which there was a significant differnce (P<0. 01) between the groups A, C and the group B. Conclusion The combined laser operation with being taken MAXVIR orally is more effective to treat RCA than acyclovir tablet only, and the patients taking MAXVIR have less side effect and more convenient and complaisant than those taking ACV. This MAXVIR synthetic treatment is an effective and safe method to cure RCA.
出处
《中国性病艾滋病防治》
2000年第1期37-39,共3页
Chinese Journal of Std & Aids Prevention and Control
