摘要
采用与类风湿性关节炎特征相似的小鼠胶原诱导性关节炎 (Collagen- induced arthritis,CIA)模型 ,以关节炎发病率、关节炎指数、抗 型胶原 (C )抗体水平、组织病理学改变等为指标 ,观察了斑蝥膏穴位敷贴 (天灸 )对此模型的影响 ,并检测了胶原免疫小鼠脾脏白介素 - 1β水平。结果显示 :督脉经穴斑蝥敷贴治疗 ,能明显抑制小鼠 CIA的发生 ,显著降低关节炎指数 ,抗 CII抗体水平和组织病理改变指数。同时表明此方法对 CIA的治疗作用与抑制内源性 IL - 1β的产生有关。
Type Ⅱ collagen-induced arthritis (CTA) in mice,which shares similar characteristics with rheumatoid arthritis,was used as the mode for RA in this study,by taking the incidence,arthritis index,the level of anti-collagenase Ⅱ antibody,the histo-pathological changes as quotas,we observed cantharis plaster's effect on the model by applicating it on acupoints(medicinal vesiculation),and measured the splenic interleukin-1 β level of collagen-immunized mice.The result showed that applicating on the acupoints of Du Meridian could apparently inhibit the onset of CIA and reduce the index of arthritis,the level of anti-C Ⅱ antibody and the histo-pathologic lesions.At the same time,it indicates that the effect of the therapy on CIA may be attributed to its inhibiting the production of endogenous IL-1β.
出处
《浙江中医学院学报》
2000年第1期72-73,共2页
Journal of Zhejiang College of Traditional Chinese Medicine
关键词
类风湿性关节炎
胶原
斑蝥
穴位敷贴
小鼠
rheumatoid arthritis
collagen
cantharis acupoint application
interleukin-1 β
