摘要
目的 本研究对40例口腔扁平苔藓(OLP)患者及40名对照组患者分别用干湿全自动生化分析仪、酶链免疫吸附试验(ELZSA)及多聚酶链反应(PCR)检测外周血ALT、抗-HCV和HCV—RNA、以探讨HCV感染与OLP之间的关系。结果 40名OLP患者中,10例(25.0%)有ALT异常,8例(20.0%)抗—HCV阳性,7例(17.5%)HCV—RNA阳性,经统计学处理有显著性差异(P<0.05、P<0.01、P<0.01),同时对两例血清HCV—RNA阳性的OLP患者用PCR法进一步检测其口腔病损组织中的HCV—RNA均为阴性。结果提示:OLP患者中HCV的高感染率,以及部分OLP患者体内有HCV—RNA存在与复制,说明部分OLP的发病可能与HCV感染有一定的关系。
To assess the association between oral lichen planus (OLP) and hepatitis C virus (HCV) infection. We selected 40 patients with OLP and 40 control patients to analysed the presence of HCV in peripheral blood by dry wet automatic biochemical analysis, antibodies to HCV by enzyme immunossay and HCV RAN by polymerase chain reaction (PCR). We found that: in these 40 patients with OLP 10(25%) had abnormal ALT, 8 Patients (20.0%) had antibodies to HCV positive, and in 7(17.5%)patients HCV-RAN was detected. Also,they had significant difference( P <0 05, P <0 01, P <0 01)by statistial analysis. Further more, we detected the HCV RNA in oral erosive tissure by polym,erase chain reaction(PCR) in two patients with positive serum HCV-RNA, both were negtive. The result indicats:The high prevemlence of HCV in patients with OLP and some of them have HCV-RNA reproduction show that the etiology of OLP may partially associat with HCV infection.
出处
《临床口腔医学杂志》
2000年第1期47-48,共2页
Journal of Clinical Stomatology
关键词
口腔
扁平苔藓
丙型肝炎
RNA
聚合酶链反应
Oral Lichen Planus Hepatitis C Virus Polymerase Chain Reaction Virus RNA
