摘要
评价左氧氟沙星治疗伤寒的临床疗效和体外抗菌活性。方法:以国产和进口左氧氟沙星片剂做随机对照试验治疗急性伤寒共30例,用药量均为200mg,每日2次,疗程7d。结果:两种药物均获得了良好的临床疗效,临床治愈率和细菌清除率均为100%,国产和进口左氧氟沙星在临床疗效和细菌学疗效方面均无差异(P>0.05),两种药对伤寒杆菌的MIC90均为0.125mgL。全部病例未见明显不良反应发生。结论:左氧氟沙星治疗伤寒临床疗效好,抗菌活性高,安全可靠。国产左氧氟沙星的疗效和进口产品相同。
An open,randomized clinical study was carried out to compare the clinical efficacy and in vitro antibacterial activity of domestic levofloxacin (LVFX) with that of import one in the treatment of typhoid fever. 30 patients affected by proven typhoid sepsis, were randomly assigned to treatment with domestic (group A) or imported levofloxacin (group B) at 200 mg, twice daily for 7 days. Results showed that two groups of patients completely recovered from infection and all isolated strains of Salmonella typhi were eradicated. No difference was found between domestic and the import LVFX in clinical cure rate and bacterial clear rate ( P >0.05). No severe adverse effects of all these agents were found during treatment. The MIC 90 of two agents were same 0.125 mg/L. Results indicate that LVFX is effective and safe in the therapy of typhoid fever, and the clinical efficacy of domestic LVFX is the same as the import one.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2000年第1期51-52,共2页
Chinese Journal of Antibiotics
