摘要
为更好地研究人体心衰的工作机制,为临床诊断与治疗提供理论依据与仿真工具,根据电网络模型法建立了一个改进型五阶集总参数心血管循环系统模型。应用Matlab软件进行仿真。结果表明:该模型简单有效,可模拟健康状态血液动力学特性,模拟得到CO(心输出量)为5.12 L/min,并可通过调节心率、心力、心室前负荷、心室后负荷模拟静息、轻度运动、中度运动、重度运动时的健康血液循环状态,模拟得出CO逐渐增大分别为5.09 L/min、8.86 L/min、10.74 L/min、14.7 L/min;也可以模拟Ⅰ级、Ⅱ级、Ⅲ级、Ⅳ级心衰的血流动力学特性,模拟得出CO逐渐减小分别为5 L/min、4.4 L/min、3.8 L/min、3.2 L/min,仿真结果与实际生理状态及文献中的试验数据相符,对诊断和治疗心衰疾病具有重要意义。
In order to deeply understand the mechanisim of heart failure and provide therapy and simulation tool for clinical diagnosis and treatment,a fifth-order lumped parameter cardiovascular system model according to electrical circuit theory was built in this paper.Using MATLAB,the simulation results show that the model is effective and it can simulate the hemodynamics of normal heart.The simulated CO（Cardiac Output） is 5.12 L/min.Under different level exercises including mild exercise,moderate exercise and severe exercise,of normal heart the simulated CO gradually increase from 5.09 L/min,8.86 L/min,10.74 L/min to 14.7 L/min.The four categories of ClassⅠ,ClassⅡ,ClassⅢ,Class Ⅳ of heart failure can be also simulated by the method.The simulated CO decrease from 5 L/min,4.4 L/min,3.8 L/min to 3.2 L/min.The results of our studies agreed well with real physiological conditions and the experimental data reported in literatures.This is important for the diagnosis and treatment of heart diseases.
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
2012年第1期13-19,共7页
Chinese Journal of Biomedical Engineering
基金
国家自然科学基金重点项目(30900289)
江苏省自然科学研究项目(04KJB310171)
江苏大学高级人才启动基金(05JDG029)
关键词
心血管循环系统
建模
仿真
血流动力学
心衰
cardiovascular system
modeling
simulation
hemodynamics
heart failure
