摘要
目的:研究乌司他丁(UTI)在感染性休克动物的心肌保护作用。方法:经腹腔内注射内毒素制作兔感染性休克动物模型,30只日本大耳白兔随机均分为模型对照组(静脉点滴生理盐水),集束化治疗组(给予集束化治疗),UTI组(集束化治疗+UTI),连续1周。模型制作前、后4周行心脏超声检查,测定血浆N末端B型脑钠肽前体(NT-proBNP)、白介素-6(IL-6)、血浆超氧化物歧化酶(SOD)水平。结果:与模型对照组和集束化组比较,UTI组NT-proBNP最低[第一周:(1034.1±52.4)ng/L比(945.1±67.1)ng/L比(789.3±59.8)ng/L,第二周:(935.6±47.8)ng/L比(831.9±57.8)ng/L比(639.3±48.7)ng/L,P均<0.05],血浆SOD水平明显升高[(4.89±0.48)U/ml比(5.15±0.68)U/ml比(6.93±0.24)U/ml,P<0.05],感染性休克后1周内IL-6明显下降[(194.5±9.2)ng/L比(152.3±11.4)ng/L比(104.1±8.3)ng/L,P<0.05],其后三组IL-6水平无显著差异。结论:乌司他丁对感染性休克心肌损伤具有保护作用,可能与抑制炎症及氧化应激等有关。
Objective：To study therapeutic effects of ulinastatin（UTI） on myocardial protection of animals with septic shock.Methods：Animal models of septic shock in rabbits were established by intraperitoneal injection of endotoxin.A total of 30 Oryctolagus cuniculus were randomly divided into model control group（received venous drip of normal saline）,cluster-based treatment group（received cluster treatment） and UTI group（received UTI treatment based on cluster treatment）,and all rabbits received treatment for one week.All rabbits underwent echocardiography examination,detections of levels of plasma N-terminal pro brain natriuretic peptide（NT-proBNP）,interleukin（IL）-6 and plasma superoxide dismutase（SOD） before and four weeks after establishment of model.Results：Compared with model control group and cluster treatment group,there was significant decrease in NT-proBNP level [first week：（1034.1±52.4） ng/L vs.（945.1±67.1） ng/L vs.（789.3±59.8） ng/L,second week：（935.6±47.8） ng/L vs.（831.9±57.8） ng/L vs.（639.3±48.7） ng/L,P〈0.05 all]and significant increase in plasma level of SOD [（4.89±0.48） U/ml vs.（5.15±0.68） U/ml vs.（6.93±0.24） U/ml,P〈0.05]in UTI group;during one week after septic shock,there was significant decrease in IL-6 level [（194.5±9.2） ng/L vs.（152.3±11.4） ng/L vs.（104.1±8.3） ng/L,P〈0.05]in UTI group,but no significant difference existed in IL-6 level among three groups afterwards.Conclusion：Ulinastatin possesses protection on impaired myocardium after septic shock,and the mechanism may be related with inhibitions of inflammation and oxidative stress.
出处
《心血管康复医学杂志》
CAS
2012年第1期73-76,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
休克
乌司他丁
心肌
Shock
Ulinastatin
Myocardium
