摘要
目的 探讨体外循环心脏手术术后早期应用乌司他丁（UTI）对患者全身炎性反应综合征的作用，及对患者早期恢复的影响。方法 体外循环人工心脏瓣膜替换术患者24例．根据是否在术后早期应用UTI随机均衡地分为处理组和对照组，回顾性观察患者全身炎性反应情况、血流动力学、呼吸功能和早期恢复情况。结果 处理组体外循环心脏术后血清细胞因子TNF-α、IL-1、IL-6和IL-8浓度显著低于对照组。处理组患者术后心输出量指数（cardiacindex，CI）、每搏量指数（strokeindex，SI）、氧合指数（oxygenindex，OI）均高于对照组；处理组术后呼吸机辅助时间、ICU停留时间均少于对照组，两组总住院时间、总住院费用无差异。结论 体外循环术后早期使用乌司他丁可以有效地缓解术后全身炎性反应，对脏器具有保护作用，有利于患者早期恢复，且不增加患者的经济负担。
Objective The article aims to investigate the utility of Ulinastatin（UTI） in inhibition of systemic inflammatory response syndrome （SIRS） and its protective effect on major organs during the post-CPB period. Methods 24 patients undergoing cardiac operation using CPB were divided into two groups randomly, according to receiving UTI injection or not. Their manifestation of SIRS, index of homodynamic and respiratory function and data of the early recovery were retrospectively analyzed. Results The respective serum concentration of TNF-α, IL-1, IL-6, and IL-8 in UTI group was lower than in the control group obviously. There were significant differences in the cardiac index （CI）, stroke index （SI） and oxygen index （OI） between the two groups. All the patients fully recovered their health after the operation. The period of ventilatory support and the ICU days in UTI group were shorter than in the control group, while there were no statistically differences in total cost of hospitalization between two groups. Conclusion An injection of UTI can inhibit the elevation of proinflammatory cytokines, thus improve the postoperative recovery of patients without any complications.
出处
《世界急危重病医学杂志》
2007年第4期1929-1933,共5页
internationl journal of emergency and critical care medicine
