摘要
目的探讨四联疗法治疗难治性消化性溃疡临床疗效。方法 86例难治性消化性溃疡患者随机分为治疗组43例,克拉霉素、替硝唑、埃索美拉唑加甘草酸铋散的四联疗法治疗;对照组43例,克拉霉素、替硝唑、埃索美拉唑三联疗法治疗。比较2组治疗后临床症状改善情况、溃疡愈合率、幽门螺杆菌清除率。结果治疗组治疗后溃疡愈合率、幽门螺杆菌清除率明显高于对照组。所有患者均未发生明显不良反应。结论四联疗法治疗难治性消化性溃疡临床疗效显著,无明显不良反应。
Objective To investigate the clinical efficacy of quadruple therapy for refractory peptic ulcer.Methods Eighty-six patients with refractory peptic ulcer were randomly divided into treatment group（n=43,treated with clarithromycin,tinidazole,esomeprazole plus glycyrrhizin bulk bismuth quadruple therapy） and control group（n=43,treated with clarithromycin,tinidazole,esomeprazole triple therapy）.Two groups were compared after treatment in terms of improvement of clinical symptoms,ulcer healing rate and H.pylori clearance.Results After treatment,the ulcer healing rate and H.pylori clearance rate of the treatment group were significantly higher than those of the control group.All patients had no obvious adverse reactions.Conclusion The clinical effect of quadruple therapy for refractory peptic ulcer is significant,and there is no obvious adverse reactions.
出处
《实用临床医药杂志》
CAS
2012年第1期77-78,共2页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11220005)
关键词
消化性溃疡
幽门螺杆菌
四联疗法
peptic ulcer
helicobacter pylori
quadruple therapy
