摘要
作者对不同病期的流行性出血热(EHF)75例进行了血浆前列环素(prostaglandin I_2,PGI_2)和血栓素A_2(thromboxane A_2,TXA_2)水平的动态观察,同时进行了某些凝血指标的监测,发现EHF各期中PGI_2和TXA_2值的波动有一定规律性。尤为突出的是,从发热期至低血压休克期PGI_2水平急骤下降,造成PGI_2/TXA_2比值严重倒置,在EHF的休克、出血和肾功能衰竭等发病机理中起重要作用。
The serial changes of plasma prostacycline (PGI2) and thromboxane A2 (TXA2) levels at different stages of epidemic hemorrhagic fever (EHF) were observed and some coagulation tests were simultaniously performed in 15 patients. It was found that the fluctuations of PGI2 and TXA2 at different stages of EHF were of certain regularity. The change in PGI2/TXA2 ratio caused by abrupt decrease of PGI2 levels from febrile stage to shock stage may play an important role in the pathogensis of shock, hemorrhage and renal failure of EHF.
出处
《上海医学》
CAS
CSCD
北大核心
1989年第3期135-138,共4页
Shanghai Medical Journal
