摘要
目的:评价不同细胞学检查方法在宫颈癌筛查中的作用,探讨宫颈癌筛查的适宜技术,以便做到早诊、早治,有效提高宫颈癌前病变的检出率。方法:采用液基薄层细胞学检测技术(LCT)及传统宫颈细胞涂片(巴氏涂片)法,分别对2005年10月～2007年6月1 091名及4 784名受检者进行宫颈癌筛查,根据细胞学结果阳性的受检者,在阴道镜下取活体组织检查(活检)行病理学检查。结果:传统细胞学涂片和液基细胞学的灵敏度、特异度、阴性预测值、阳性预测值、符合率分别为:44.44%、83.33%、30.00%、90.32%、77.95%和92.10%、88.37%、77.78、96.20%、89.52%;液基细胞学对子宫颈癌前病变的检出率(91.67%)高于巴氏涂片(40.00%),差异有统计学意义(P<0.05)。结论:液基细胞学检查敏感性明显高于传统宫颈细胞涂片法,能大大提高检出率,尤其是对LSIL和HSIL的患者。
Objective：To evaluate the effects of different methods for cytological examination in cervical cancer screening,explore the appropriate techniques for screening of cervical cancer,in order to conduct early diagnosis and early treatment,improve the detection rate of precancerous lesions of uterine cervix.Methods：Liquid-based cytological test and traditional Papanicolaou smear were used for cervical cancer screening among 1 091 cases and 4 784 cases respectively from October 2005 to June 2007,then the cases with positive results of cytological examination underwent biopsy under colposcope and pathological examination.Results：The sensitivity,specificity,negative predictive value,positive predictive value,and coincidence rate of traditional Papanicolaou smear were 44.44%,83.33%,30.0%,83.33%,and 77.95 %,respectively;the sensitivity,specificity,negative predictive value,positive predictive value,and coincidence rate of traditional Papanicolaou smear were 92.11%,88.37%,77.78,88.37%,and 89.52%,respectively.The detection rate of precancerous lesions of uterine cervix by liquid-based cytological test was 91.67%,which was significantly higher than that by traditional Papanicolaou smear（40.00%）（P0.05）.Conclusion：The sensitivity of liquid-based cytological test is significantly higher than that of traditional Papanicolaou smear,liquid-based cytological test can improve the detection rate obviously,especially for the cases with low-grade squamous intraepithelial lesion（LSIL） and high-grade squamous intraepithelial lesion（HSIL）.
出处
《中国妇幼保健》
CAS
北大核心
2012年第6期917-919,共3页
Maternal and Child Health Care of China
关键词
液基薄层细胞学
巴氏涂片
宫颈癌筛查
检出率
Liquid-based cytological test
Papanicolaou smear
Cervical cancer screening
Detection rate
