摘要
目的:探讨产前筛查在孕中期产前诊断中的价值。方法:2006年1月～2009年9月对2 880例孕16～20周的妇女行产前筛查,检测其血清中甲胎蛋白(AFP)、游离β绒毛膜促性腺激素(F-βHCG)和游离雌三醇(μE3)浓度,结合年龄、体重等因素,评定危险系数。高危孕妇进行羊膜腔穿刺,羊水细胞染色体核型检查以确诊。结果:共有2 880例孕妇接受筛查。其中筛出唐氏综合征(DS)高风险5例,经羊水细胞染色体核型分析确诊2例;18-三体高风险2例,确诊1例:神经管缺陷(NTD)高风险2例,确诊2例。所有筛查孕妇均随访至胎儿出生,1例筛查阴性的孕妇分娩唐氏儿。结论:产前筛查可提高先天缺陷儿的检出率,是提高出生人口素质的有效技术措施。
Objective：To explore the value of prenatal screening in prenatal diagnosis of women during the second trimester of pregnancy.Methods：A total of 2 880 women during 16-20 gestational weeks received prenatal screening from January 2006 to September 2009,the serum levels of alpha fetoprotein（AFP）,free human β gonadotropin（F-βHCG）,and free estriol were detected,the risk index was evaluated combined with other factors,such as age and body weight.The high risk pregnant women underwent amniocentesis,then they were diagnosed definitely by chromosomal karyotype test of amniotic fluid cells.Results：A total of 2 880 pregnant women received prenatal screening,five pregnant women were found with high risk of Down＇s syndrome,after chromosomal karyotype test of amniotic fluid cells,two pregnant women were diagnosed definitely;two pregnant women were found with high risk of trisomy 18,after chromosomal karyotype test of amniotic fluid cells,one pregnant woman was diagnosed definitely;two pregnant women were found with high risk of neural tube defect,after chromosomal karyotype test of amniotic fluid cells,two pregnant women were diagnosed definitely.All the pregnant women were followed up until the birth of the fetuses,one pregnant woman with negative result of prenatal screening gave birth to a infant with Down＇s syndrome.Conclusion：Prenatal screening can improve the detection rate of the infants with congenital defects,which is an effective measure to improve the quality of birth population.
出处
《中国妇幼保健》
CAS
北大核心
2012年第6期863-865,共3页
Maternal and Child Health Care of China
关键词
唐氏综合征
神经管缺陷
产前筛查
Down＇s syndrome
Neural tube defect
Prenatal screening
