摘要
目的探讨2型糖尿病(T2DM)是否为胃癌发病的危险因素。方法随机选取曾在我院住院的胃癌患者296例(胃癌组),并随机选取住我院的非胃癌患者302例作为对照组。采用病例对照的方法,回顾性分析两组的糖尿病患病情况、胃炎病史、饮酒、吸烟、胃癌家族史的差异。结果胃癌组中合并糖尿病者59例(19.9%),对照组中合并糖尿病者31例(10.3%),两组差异有统计学意义(P=0.036)。胃癌组的男性患2型糖尿病的OR值为9.89,女性患者患2型糖尿病的OR值为8.26,男女间比较无显著性差异。单因素回归分析提示,年龄、吸烟、饮酒、胃炎、胃癌家族史、DM与胃癌的发病有关,最终年龄、饮酒、胃炎、T2DM进入多因素非条件回归模型,其OR值分别是1.357、3.013、4.631和3.962。结论年龄、饮酒、胃炎和T2DM是胃癌的危险因素。在4种危险因素当中,T2DM危险程度仅次于胃炎,并且这些因素存在相互促进作用。
Objective To discuss whether type 2 diabetes mellitus（T2DM）is the risk factor of the morbidity of gastric cancer.Methods 296 patients with gastric cancer（gastric cancer group）and 302 patients without gastric cancer（control group）,who were all admitted in our hospital,were randomly selected.The method of case control was used to analyze retrospectively the differences of diabetes pathogenetic condition,gastritis history,drinking,smoking and family history of gastric cancer between the two groups.Results There were 59 patients with DM in the gastric cancer group（19.9%）and 31 patients with DM in the control group（10.3%）.The differences between the two groups were significant（P=0.036）.The OR value of the male patients with T2DM in the gastric group was 9.89,while among the female patients in this group the OR value was 8.26.There was no obvious difference between the two genders.The single factor regression analysis indicated that age,smoking,drinking,gastritis,family history of gastric cancer and DM were correlated with the morbidity of gastric cancer.Age,drinking,gastritis and T2DM entered the multiple factor non-conditional regression model,and the OR value was 1.357,3.013,4.631 and 3.962,respectively.Conclusion Age,drinking,gastritis and T2DM are the risk factors of gastric cancer.T2DM is the risk factor only second to gastritis,and there were synergistic effects among these factors.
出处
《西南国防医药》
CAS
2012年第2期138-141,共4页
Medical Journal of National Defending Forces in Southwest China
关键词
糖尿病
胃癌
危险因素
diabetes mellitus
gastric cancer
risk factor
