摘要
目的探讨肺表面活性物质(pulmonary surfactant,PS)治疗新生儿呼吸窘迫综合征(neonatal respiratory distress syn-drome,NRDS)对患儿病情变化和转归结果的影响。方法对2007年6月～2009年6月笔者医院新生儿重症监护中心(neonatalintensive care unit,NICU)收治的43例NRDS患儿使用PS情况及转归结果进行统计调查分析,根据是否使用PS分为PS使用组和PS未用组,对两组患儿的一般临床情况、呼吸支持情况、症状变化及转归结果进行回顾性分析。结果调查发现NRDS患儿胎龄和出生体重均较低(分别为31.0±1.5周和1.734±0.170kg);与PS未用组比较,PS使用组NRDS患儿支气管肺发育不良(bronchopulmonary dysplasia,BPD)的发生率差异无统计学意义,但脑室内出血(intraventricular hemorrhage,IVH)、早产儿视网膜病(retinopathy of prematurity,ROP)的发生率、病死率和住院时间均明显降低,呼吸窘迫或呼吸困难等症状消失的时间明显缩短,接受机械通气或NCPAP的时间明显减少。结论 NRDS使用PS后虽不能完全改变转归和预后,但能有效地改善患儿肺顺应性及氧合功能,缩短需要机械通气及氧疗时间,提高患儿成活率,缩短住院时间。
To investigate the effects of using pulmonary surfactant to treat neonatal respiratory distress syndrome （NRDS） on the prognosis. Methods Totally 43 infants of neonatal respiratory distress syndrome （NRDS） in NICU of our hospital from June 2007 to June 2009 were retrospectively analyzed. We analyzed the turnover of using pulmonary surfactant to treat NRDS. According to whether the using of PS, 43 infants of NRDS were divided into groups of using PS and groups of no using PS. We retrospectively ana- lyzed their clinical cases, breath supporting cases, symptoms changes, prognosis. Results The gestation age of NRDS was 31.0 ± 1.5 weeks, birth weight 1. 734 ：± 0. 170kg. Compared with the gourp of no using PS, the incidence of bronchopulmonary dysplasia （BPD） was not statistically significant in gourp of using PS. But the incidence of intraventricular hemorrhage （IVH） and retinopathy of prematurity （ROP） was obviously reduced, the case fatality and length of stay were also obviously reduced, the syndrome of respiratory distress shortly disappeared, the time of mechanical ventilation or NCPAP were obviously reduced. Conclusion After using pulmonary surfactant, al- though the prognosis and turnover of NRDS were not completely altered, it can be effectively improve pulmonary compliance and oxygena- tion, and can reduce the time of mechanical ventilation and oxygen therapy, increase survival rate, reduce length of stay.
出处
《医学研究杂志》
2012年第1期112-114,共3页
Journal of Medical Research
关键词
肺表面活性物质
婴儿新生
呼吸窘迫征
转归
Pulmonary surfactant
Infants
Neonatal
Respiratory distress syndrome
Turnover
