摘要
目的:制备别嘌醇缓释微丸,考察其释药机制。方法:采用正交试验法进行处方筛选优化,用数学模型拟合释放曲线。结果:微晶纤维素(MCC)的用量对微丸的成球性、释药速率有显著的影响,别嘌醇缓释微丸的体外释药行为符合Higuchi方程释放模型。结论:制备别嘌醇缓释微丸具有较好的缓释效果。
Objective： To prepare allopurinol sustained-release pellets and investigate the drug release mechanism. Method： An orthogonal experiment was designed to Optimize the formulation of the allopurinol sustained-release pellets and a mathematical model was fitted to the release profiles. Result： The effect of microcrystalline cellulose （MCC） amount on the pellet formation and release was significant. The in vitro release behavior of the prepared allopurinol sustained-release pellets was fitted to the Higuchi release model. Conclusion： The allopurinol sustained-release pellets show promising sustained-release property in vitro.
出处
《中国药师》
CAS
2012年第1期35-38,共4页
China Pharmacist
关键词
别嘌醇
缓释微丸
挤出滚圆法
释放度
Allopurinol
Sustained-release p.ellets
Extrusion-spheronization
Release rate
