摘要
哺乳动物雷帕霉素靶蛋白(mTOR)是丝氨酸/苏氨酸蛋白激酶,在感受营养信号、调节细胞生长与增殖中起着关键性的作用。mTOR可磷酸化核糖体40S小亚基S6K蛋白激酶和真核起始因子4E结合蛋白1,促进蛋白质合成。磷脂酰肌醇3激酶/蛋白激酶B和蛋白激酶B/肿瘤抑制因子1～2两条信号通路都可调控mTOR活性,进而调节细胞的生长与增殖。维生素K3是一类化学合成的脂溶性维生素,已有研究表明维生素K3可抑制肿瘤细胞增殖,其机制与降低mTOR信号转导蛋白及细胞周期蛋白D1的基因表达有关。
The mammalian target of rapamycin（mTOR）is a serine/threonine protein kinase that plays a crucial role in the nutrient-sensitive signalling pathway and the regulation of cell growth and proliferation.mTOR phosphorylates p70S6K and eIF4E binding protein-1 to promote mRNA translation.Two signaling pathways,i.e.PI3K/Akt and Akt/TSC1-TSC2 pathway,have been demonstrated to be critical in the regulation of mTOR activity.VK3 can inhibit HeLa cell proliferation through oxidative stress,which might be correlated with down regulation of the genes expressions of mTOR signal pathway and cyclin D1.
出处
《医学综述》
2012年第2期203-207,共5页
Medical Recapitulate
