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缺血/再灌注过程中心肌细胞自噬研究进展 被引量：26

Role of autophagy in cardiac myocyte during ischemia/reperfusion
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摘要 自噬是一种广泛存在于真核细胞中的生命现象,心肌细胞营养缺乏、缺血/再灌注损伤、心衰等均可诱发细胞自噬。缺血/再灌注过程中的心肌细胞自噬可以维持心肌细胞稳态、减少细胞缺失,但是自噬作用也可导致心肌细胞死亡。 Autophagy is a ubiquitous physiological process that occurs in all eukaryotic cells. It can be induced by starvation, ischemia/reperfusion injury and heart failure. Rational autoph- agy in cardiac cells during ischemia/reperfusion helps to keep cellular homeostasis, and inhibit the cell loss. However, inap- propriate activation of autophagy leads to cell death.
作者 李欣志 刘建勋
机构地区 中国中医科学院西苑医院实验研究中心
出处 《中国药理学通报》 CAS CSCD 北大核心 2008年第6期704-707,共4页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No30672638)
关键词 自噬 缺血/再灌注 心肌细胞 autophagy ischemia/reperfusion cardiac myocyte
分类号 R-05 [医药卫生] R322.22 [医药卫生—人体解剖和组织胚胎学]
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参考文献27

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二级参考文献25

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共引文献21

同被引文献298

引证文献26

二级引证文献216

中国药理学通报
2008年 第6期

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