摘要
目的研究大黄对创伤性休克后并发胃肠功能障碍的作用及对体内炎症因子IL-1、Il-6及TNF-α的影响。方法将60例创伤性休克后出现胃肠功能障碍及脓毒血症患者随机分为治疗组及对照组,治疗组每天给予40g大黄加常规治疗,对照组给予常规治疗,观察两组患者胃肠功能障碍改善及治疗前后1d、5d、10d血清炎症因子IL-1β、IL-6及TNF-α的水平。结果大黄治疗组胃肠功能障碍恢复23例,肠功能障碍时间为(1.7±0.9)d,对照组胃肠功能障碍恢复13例,肠功能障碍时间为(3.8±1.7)d;治疗前,两组炎症因子基线水平一致,随时间推移,两组上述因子水平均升高,在治疗第5天开始回落,第10天降至最低,但治疗组炎症因子水平低于对照组,其中以第5天的TNF-α、IL-1β、第10天的IL-1β最为明显且差异具有统计意义(P<0.05,P<0.01,P<0.05)。结论大黄能保护胃肠黏膜、抑制毒素的移位、降低炎症因子水平,改善创伤性休克后的胃肠功能障碍。
Objective To investigate the effects of rheum officinale baill on gastrointestinal dysfunction,and influence on inflammatory factor IL-1,IL-6,TNF-α in traumatic shock patients.Methods 60 traumatic shock patients with septicopyemia and gastrointestinal dysfunction were divided into treatment group and control group.All patients were given the regular anti-shock therapy;the treatment group was added to rheum officinale baill 40 g/day for 10 days.The change of gastrointestinal dysfunction were observed,and serum IL-1β,IL-6,TNF-α levels were measured before treatments and 1 days,5 days,10 days after treatments.Results There were 23 cases recovered gastrointestinal dysfunction in treatment group,with bowel dysfunction time of（1.7±0.9） days;There were 13 cases recovered gastrointestinal dysfunction in control group,with bowel dysfunction time of（3.8±1.7） days.Before treatment,two groups baseline levels of inflammatory cytokines were consistent with each other,and over time,two factor levels were elevated above,the first 5 days of treatment began to fall,10 days to the minimum,but the levels of inflammatory factors in the treatment group than that in the control group,of which 5 days TNF-α,IL-1β,the first 10 days of IL-1β was most obvious and statistically significant（P0.05,P0.01,P0.05）.Conclusion Rheum officinale baill can ameliorate gastrointestinal dysfunction after traumatic shock,reduce inflammatory factor levels,impress the migration of toxin,and protect the gastrointestinal mucous membrane.
出处
《海南医学》
CAS
2012年第2期38-40,共3页
Hainan Medical Journal
关键词
大黄
创伤性休克
胃肠功能障碍
脓毒血症
炎症因子
Rheum officinale baill
Traumatic shock
Gastrointestinal dysfunction
Septicopyemia
Inflammatory factor
