摘要
目的探讨术前区域动脉灌注生长抑素和黄芪注射液对结肠癌细胞增殖、凋亡和血管形成的影响。方法将60例结肠癌患者随机分为生长抑素联合黄芪注射液组(A组)、单纯生长抑素组(B组)、单纯黄芪注射液组(C组)、0.9%氯化钠溶液(D组),每组15例,分别于术前区域动脉灌注对应药物+常规化疗药物。观察各组肿瘤血管密度(MVD)、VEGF染色结果、Ki标记指数(Ki67LI)及凋亡指数(AL)等差异。结果 A、B、C、D4组MVD分别为(10±6,16±8,19±6,29±15),VEGF表达分别为(20%,46.67%,53.33%,80%),Ki67LI分别为(8±3,13±5,14±5,18±6),ALI分别为(5.6±0.6,3.1±0.4,2.9±0.6,1.2±0.3)。A组与B、C2组差异有统计学意义(P<0.05)。结论区域动脉灌注化疗能促进细胞凋亡,并对肿瘤增殖有抑制作用,加入生长抑素联合黄芪比单独应用生长抑素或黄芪更能显著提高结肠癌的疗效,以增强其抗肿瘤作用。
Objective To evaluate the influence of preoperative regional intra-arterial infusion somatostatin and Astragalus on the proliferation,apoptosis and angiogenesis of colorectal carcinoma.Methods 60 patients with colon cancer were randomly divided into four groups,with 15 patients in each group,which were somatostatin combined with Astragalus injection group (group A),simple somatostatin group (group B),simple Astragalus group (group C),0.9% sodium chloride solution group (group D),respectively.These patients were treated by preoperative intra-arterial infusion with corresponding drugs plus routine chemotherapeutics.The changes of tumor blood vessel density (MVD),VEGF staining,Ki labeling index (Ki67LI) and apoptosis index (AI) were observed.Results The MVD in group A,B,C,D was 10±6,16±8,19±6,29±15,respectively,the expression of VEGF was 20%,46.67%,53.33%,80%,respectively,and Ki67LI was 8±3,13±5,14±5,18±6,respectively,and AI was 5.6±0.6,3.1±0.4,2.9±0.6,1.2±0.3,respectively.There were significant differences in these data between group A and group B,group C (P<0.05).Conclusion The regional intra-arterial infusion can promote cell apoptosis and inhibit proliferation of carcinoma,and the therapeutic effect of adding somatostatin combined with Astragalus is superior to that of simple somatostatin or simple Astragalus on colon cabcer,which can enhance anti-tumor effect.
出处
《河北医药》
CAS
2012年第2期170-172,共3页
Hebei Medical Journal
关键词
区域动脉灌注
生长抑素
黄芪
结肠癌
血管形成
regional intra-arterial infusion
somatostatin
Astragalus
colon cancer
angiogenesis
