摘要
目的 探讨术前区域动脉灌注生长抑素和化疗药物对细胞增殖、凋亡和血管形成的影响。方法 结肠癌病人45例，随机分为A．B和C组，每组15例。A组为术前加入善宁的区域动脉灌注化疗组，B组为术前不加入善宁的区域动脉灌注化疗组，C组不采用区域动脉灌注化疗常规手术组。区域动脉灌注化疗7～10d后行肿瘤切除手术。切除标本行MVD、VEGF、Ki67LI、ALI检测。结果 A、B、C组MVD分别为12±8、25±17、26±16（P〈0．05）；VEGF表达分别为39．2％、70．0％、72．4％；Ki67L1分别为（8±4）％、（11±6）％、（16±7）％（P〈0．05）；ALI分别为（4．3±0．5）％、（2．2±0．6）％、（1．5±0．6）％（P〈0．05）。区域动脉灌注化疗可以对肿瘤增殖有抑制作用，并可以促进细胞凋亡，加入善宁可以加强其上述作用外，对肿瘤血管形成具有抑制作用。结论 术前区域动脉灌注化疗药物，可以提高结肠癌的疗效，生长抑素可以增强其抗肿瘤作用。
Objective To evaluate the influence of preoperative regional intra-arterial chemotherapy （PRAC） with somatostatin and chemotherapeutic agents on proliferation, apoptosis and angiogenesis of colorectal carcinoma. Methods 45 patients with colorectal carcinoma were randomized into 3 groups in which 15 patients each group： group A （PRAC with somatostatin and chemotherapeutic agents）; group B （PRAC with chemotherapeutic agents only）; and group C （without PRAC）. Patients received radical cancer resection 7-10d after PRAC. The expression of MVD, VEGF, Ki67 LI and ALI were documented. Results In 3 groups, MVD was 12±8, 25±17, and 26±16. VEGF was 39.2%, 70.0%, and 72.4%. Ki67LI was （8±4）%, （11±6）%, and （16 ± 7）% and ALl was （4.3 ± 0.5）%, （2.2 ± 0.6）% and （1.5 ± 0.6）%, respectively. PRAC with chemotherapeutic agents could inhibit the proliferation and induce apoptosis of tumor, which combined with somatostatin could play synergic role and inhibit angiogenesis of tumor. Conclusion PRAC with chemotherapeutic agents could improve the therapeutic effect of colorectal cancer which combined with somatostatin could enhanced its efficacy.
出处
《世界肿瘤杂志》
2005年第4期259-261,共3页
Tumour Journal of the World
基金
上海市卫生系统学科带头人培养计划基金（编号1999-02）
