摘要
目的:评价升丹类含汞中医传统制剂外用的安全性。方法:选择30例符合纳入标准的粉刺性乳痈患者,以1.5 mg/cm2的剂量将九一丹均匀布撒于扩大清创术术后疮面,每日1次,根据疮面脓腐脱落情况连续给药7～14 d。检测外用九一丹前、用药不同时点和停药后不同时点的血汞、尿汞、血常规、肝肾功能及24 h尿生化等安全性指标,以评价一定时间内疮面外用九一丹的安全性。结果:九一丹以1.5 mg/cm2的剂量连续外用7～11 d,总剂量<1.85 g时,给药期间和停药3个月内机体存在汞吸收,但无急性或慢性汞中毒的临床表现。结论:九一丹外用是比较安全的。
Objective： To evaluate the safety of Chinese mercury-containing medicine for external use.Methods： Thirty patients with acne mastitis were treated with ＂Jiuyi Pellet＂ externally on the wound surface of postoperative debridement,a dose of 1.5mg/cm2,once a day,continuous administration from 7 to 14 days according to wound pus.The blood mercury,urine mercury,blood routine,liver and kidney function,and 24 hour urinary biochemical indexes were detected before treatment,during treatment at different times and after treatment to evaluate the safety of ＂Jiuyi Pellet＂ for external use.Results： ＂Jiuyi Pellet＂ was used externally for 7-14 days at 1.5 mg/cm2 dose,and the total dosage was less than 1.85 g,there was mercury absorption existed during treatment and after treatment in 3 months without acute or chronic hydrargyrism.Conclusion： External use of ＂Jiuyi Pellet＂ is safe.
出处
《上海中医药大学学报》
CAS
2012年第1期45-48,共4页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
国家"十一五"科技支撑计划基金资助项目(2008BAI53B083)
上海市浦东新区科技发展基金创新项目(PKJ2008-Y10)
关键词
九一丹
粉刺性乳痈
外治法
安全性
＂Jiuyi Pellet＂
acne mastitis
external therapy
safety
