摘要
本文对在国家金属汞浓度卫生标准下作业的48名日光灯管厂工人,同时测定了血尿γ-GT、β_2-MG、Cr及尿Hg,并以上海59名园艺工人为对照组比较研究。结果:接汞组尿γ-GT30.64±9.66U/gCr,对照组23.91±6.49U/g Cr(P<0.05);接汞组尿β_2-MG345.32±613.83μg/g Cr,对照组96.93±67.91μg/gCr(P<0.01),二者均有显著差异;接汞组尿γ-GT、β_2-MG异常率为22.93％和20.83％,与对照组亦有显著差异(P<0.01,0.05)。尿γ-GT异常者11例与尿汞、工龄及尿β_2-MG等均无显著相关。提示尿γ-GT、β_2-MG为肾损伤的敏感指标,若与尿汞监测联合使用,可提高其临床早期诊断价值。
Urine and/or serum gamma-glutamyltransferase (r-GT), beta-2-microglobulin (β_2-MG), creatinine (Cr) and mercury(Hg) weredetermined in 48 workers exposed to mercuryat a fluorescent lamp factory (the study gro-up) and in 59 horticultural workers (the co-ntrol group). Comparision of the results obta-ined from the two groups showed a significa-nt difference in r-GT (30.64±9.66 u/gCr ve-rsus 23.91±6.49u/gCr, P<O.05> and β_2-MG(345.32±613.83μg/gCr versus 96.93±67.91μg/gCr, P<0.01). Rate of abnormal urine r-GT(22.93 percent)and β_2-MG(20.83 percent)in the study group was significant as compa-red with that in the control group. Indicatingthat urine r-GT and β_2-MG are two sensitiveindexes of renal impairment, which may beof clinical value in helping early diagnosis ofchronic renal imapirment if used in combination with urine Hg determination.
出处
《中国工业医学杂志》
CAS
1993年第3期143-145,共3页
Chinese Journal of Industrial Medicine
关键词
汞
肾
损伤
汞中毒
职业病
mercury
renal impairment
urine r-GT
urine β_2-MG
