摘要
目的探讨苦碟子注射液联合脑蛋白水解物治疗急性脑梗死（ACI）的疗效。方法将72例ACI患者按入院先后顺序分为两组，治疗组37例采用苦碟子注射液联合脑蛋白水解物治疗，对照组35例单纯给予脑蛋白水解物治疤均每日1次，14d为1个疗程。以脑血流动力学、血液流变学及临床表现的改善程度判定其疗效。结果治疗后两组患者椎基底动脉系统、颈内动脉系统平均血流速度（Vm）均较治疗前明显增快，治疗组较对照组增长更加明显[右侧大脑前动脉（ACA，cm／s）：45．76±4．64比44．23±4．40，右侧大脑中动脉（MCA，cm／s）：58．22±5．08比56．86±5．18，左侧ACA（cm／s）：45．83±4．85比42．54±5．62，左侧MCA（cm／s）：59．82±5．24比55．27±5．43，右侧椎动脉（VA，cm／s）：35．23±3．52比29．32±3．32，左侧VA（cm／s）：33．52±3．04比29．84±3．52，基底动脉（BA，cm／s）：38．83±3．46比35．88±4．24]，差异均有统计学意义（均P〈0．05）；治疗后两组血液流变学指标均有改善，治疗组较对照组改善明显[全血黏度切变率（mPa·S）200·s-1：4．42±0．58比5．23±0．46，5·s-1：9．13±0．88比11．24±0．56；血浆黏度（mPa·s）：1．16±0．15比1．42±0．14，红细胞聚集指数：4．23±0．26比4．48±0．323，差异均有统计学意义（均P〈0．05）；治疗组临床总有效率明显高于对照组（86．5％比62．8％，P〈0．05）。结论苦碟子注射液联合脑蛋白水解物治疗ACI能够改善患者脑供血，降低血黏度。具有较好的临床疗效。
Objective To investigate the therapeutic effects of combination of Kudiezi injection and brain protein hydrolysate for treatment of patients with acute cerebral infarction （ ACI ） . Methods Seventy-two cases of ACI were randomly divided into two groups, 37 cases in the treatment group received Kudiezi injection combined with brain protein bydrolysate treatment, another 35 cases obtained brain protein hydrolysate treatment only as the control group, and the treatment was given once a day in both groups, 14 days constituting one therapeutic course. The efficacy was judged through cerebral hemodynamics, hemorheology and improvement in clinical manifestations. Results After treatment, the average flow velocities （ Vm ） of vertehrobasilar artery and internal carotid artery systems were increased significantly in patients of the two groups, and compared with the control group, the changes in the treatment group were more obvious [right anterior cerebral artery （ACA, cm/s） ： 45.76±4.64 vs. 44.23±4.40, the right middle cerebral artery （MCA, cm/s） ： 58.22±5.08 vs. 56.86±5.18, the left ACA （cm/s） ：45.83±4.85 vs.42.54±5.62, the left MCA （em/s） ： 59.82±5.24 vs. 55.27±5.43, right vertebral artery （VA, cm/s） ： 35.23±3.52 vs. 29.32±3.32, left VA （cm/s） ： 33.52±3.04 vs. 29.84±3.52, basilar artery （BA, em/s） ： 38.83±3.46 vs. 35.88±4.243, and the differences were statistically significant （all P 〈 0.05）. The blood rhoology indexes were improved after treatment in the two groups, and the index in treatment group was improved more remarkably than that in control group [the whole blood viscosity and shear rate （mPa. s） 200. s-1： 4.42±0.58 vs. 5.23±0.46, 5. s-1： 9.13±0.88 vs.11.24±0.56; plasma viscosity （mPa-s） ： 1.16±0.15 vs.1.42±0.14, erythrocyte aggregation index： 4.23±_0.26 vs. 4.48±0.32], the differences being statistically significant （ all P〈0.05 ） . The clinical total effective rate in treatment group was significantly higher than that in control group （ 86.5% vs. 62.8%, P〈0.05 ）. Conclusion The combination of Kudiezi injection and brain protein hydrolysate in treatment of ACI can improve the patient＇s cerebral blood suoolv, reduce blood viscosity, thus it has good clinical therapeutic effect.
出处
《中国中西医结合急救杂志》
CAS
北大核心
2012年第1期9-11,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
国家自然科学基金资助项目（11102235）
武警医学院科研立项课题（WYM201118）
