摘要
目的 探讨心型脂肪酸结合蛋白（H-FABP）对急性心肌梗死（AMI）的早期诊断价值.方法 采用固相夹心酶联免疫法（ELISA）测定64例AMI患者血浆肌钙蛋白T（cTnT）、肌酸激酶同工酶（CK-MB）、肌红蛋白（MYO）和H-FABP浓度;同时选取53例患者作为对照组.H-FABP采用两种检测方法：固相夹心酶联免疫法和胶乳比浊法免疫测定（LTIA）.结果 cTnT、CK-MB、MYO、H-FABP（by ELISA）、H-FABP（by LTIA）和ECG（心电图）诊断AMI的敏感性分别为39.1%、59.4%、64.1%、68.7%、70.3%和54.7%,特异性为98.1%、71.7%、81.1%、77.4%、90.6%和92.5%.结论 对AMI患者的诊断,H-FABP （by LTIA）优于cTnT、CK-MB、MYO、H-FABP （by ELISA）和ECG.
Objective To investigate the early diagnosis value of heart-type fatty acid-binding protein （H-FABP） assay with other cardiac-markers in aeute myocardial infarction （AMI）. Methods The plasma H- FABP, eTnT, CK-MB and MYO concentrations were measured in 64 patients with AMI. Meanwhile 53 people were also selected as the control group. H-FABP was measured by using 2 immunoassays, the H-FABP enzyme- linked immunosorbent assay（ELISA） and the H-FABP latex turbidimetric immunoassay（LTIA）. Results Sensitiv- ities of assays for cTnT, CK-MB, MYO, H-FABP （by ELISA）, H-FABP （by LTIA）, and electrocardiogram （ECG） for the diagnosis of AMI were 39.1%, 59.4%, 64.1%,68.7%, 70.3% and 54.7%, respectively. Speeifiei- ties of cTnT, CK-MB, myoglobin, H-FABP （by ELISA）, H-FABP （by LTIA）, and ECG were 98.1%, 71.7%, 81.1%, 77.4%, 90.6%, and 92.5%, respectively. Conclusion H-FABP （by LTIA） is superior to eTnT, CK- MB, MYO, and H-FABP （by ELISA） tests for the early diagnosis of AMI in patients .
出处
《中国心血管病研究》
CAS
2012年第1期43-46,共4页
Chinese Journal of Cardiovascular Research
关键词
胶乳比浊法免疫测定
心型脂肪酸结合蛋白
早期诊断
急性心肌梗死
Latex turbidimetric immunoassay
Heart-type fatty acid-binding protein
Early diagnosis
Acute myocardial infarction
