摘要
目的:探讨冠心病(CHD)患者同型半胱氨酸(Hcy)、脑钠肽(BNP)与冠状动脉病变程度的关系及临床意义。方法:选择CHD患者80例,根据临床表现,心电图变化及心肌损伤标志物水平分为急性心肌梗死组(AMI组),不稳定型心绞痛组(UAP组)和稳定型心绞痛组(SAP组),并设正常对照组58例,测定所有研究对象血浆Hcy、BNP水平,并进行组间对比。结果:AMI、UAP组及SAP组血浆Hcy[(26.72±4.62)μmol/L比(20.28±4.05)μmol/L比(15.34±3.93)μmol/L]、BNP[(480.27±70.84)pg/ml比(312.25±62.54)pg/ml比(215.78±68.27)pg/ml]水平均明显高于正常对照组的[(11.27±3.58)μmol/L,(35.14±17.12)pg/ml],各组间比较差异均有显著性(P均<0.05);随着冠状动脉病变Gensini评分的增加,Hcy、BNP浓度明显升高(P<0.05)。结论:冠心病患者血浆同型半胱氨酸、脑钠肽水平明显升高,与冠状动脉病变程度有关。
Objective：To study the correlation among plasma homocysteine（Hcy）,brain natriuretic peptide（BNP） and severity of coronary artery lesions in patients with coronary heart disease（CHD） and their clinical significance.Methods：According to clinical symptoms,changes of electrocardiogram and levels of markers for myocardial damage,a total of 80 CHD patients were divided into acute myocardial infarction group（AMI group,n=31）,unstable angina pectoris group（UAP group,n= 29） and stable angina pectoris group（SAP group,n=20）.Another 58 cases were regard as normal control group.Plasma levels of Hcy and BNP were measured in all cases.Results：Plasma levels of Hcy [（26.72±4.62） μmol/L vs.（20.28±4.05） μmol/L vs.（15.34±3.93） μmol/L] and BNP [（480.27±70.84）pg/ml vs.（312.25±62.54）pg/ml vs.（215.78±68.27） pg/ml] in AMI,UAP and SAP group were respectively significantly higher than those of normal control group [Hcy：（11.27±3.58） μmol/L,BNP：（35.14±17.12） pg/ml]（P〈0.05 all）;As Gensini scores of coronary artery lesions increased,concentrations of Hcy and BNP significantly increased（P〈0.05）.Conclusion：Plasma levels of homocysteine and brain natriuretic peptide significantly increase in patients with coronary heart disease,and they are related to the severity of coronary artery lesions.
出处
《心血管康复医学杂志》
CAS
2011年第4期342-345,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
冠状动脉疾病
半胱氨酸
利钠肽
脑
Coronary artery disease
Cysteine
Natriuretic peptide
brain
