摘要
目的 了解P2 1对职业性肺癌的预报价值。方法 用WesternBlotting免疫印迹法对2 0名沥青工、焦炉工和 12名对照者血清P2 1水平进行了追踪观察。结果 2 0名沥青工、焦炉工的血清P2 1水平有上下波动现象 ;他们的第 2次P2 1检测值 (3773.3± 10 33.7)高于第 1次 (34 84.4±1915 .8) ,但差异无显著性 (P >0 .0 5 ) ;接触组的这两次P2 1检测值 (34 84.4± 1915 .8、3773.3±10 33.7)始终高于对照组 (1199.8± 75 7.3、12 70 .7± 6 34 .7) ,差异有显著性 (P <0 .0 1)。结论 多环芳烃类混合物具有较强的遗传毒性 ,可使职业工人在早期接触阶段出现P2 1的高表达。
Objective To explore the role of P21 in predication of occupational lung cancer. Methods Serum P21 levels from 20 workers exposed to coal tar pitch(CTP) and to coke oven volatiles(COV) and from 12 cases of normal controls were longitudinally studied with the method of Western Blotting. Results It was found that some individual P21 went up and the others went down.P21 level in the exposed workers detected at the second time (3 773.3± 1 033.7) was not significantly different from that at the first time (3 484.4± 1 915.8, P >0.05).P21 levels in exposure group(3 484.4±1 915.8, 3 773.3± 1 033.7 respectively) were significantly higher than that in control (1 199.8± 757.3, 1 270.7± 634.7 respectively). Conclusion Polycyclic aromatic hydrocarbons(PAHs) has a strong genetic toxic effect and can cause P21 level increase in earlier stage among occupational workers.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
2000年第1期49-50,共2页
Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词
血清P21
职业接触
多环芳烃
PAHS
肺癌
Serum P21
Occupational exposure
Polycyclic aromatic hydrocarbons(PAHs)
