摘要
目的··:探讨丁丙诺啡对阿片类药物依赖的治疗作用。方法··:以生理盐水为对照组 ,应用丁丙诺啡对吗啡依赖大鼠进行脱毒治疗 ,分别于停用吗啡24h,72h,8d观察其对湿狗样抖动、齿颤等戒断症状的影响及位置偏爱实验吗啡侧停留时间。结果··:丁丙诺啡能明显地缓解和控制戒断症状 ,递减顺利 ,但不能改变大鼠在吗啡侧停留时间。结论··:丁丙诺啡脱毒治疗没有明显改变依赖大鼠对阿片类药物的精神依赖 。
Objective: To study the efficacy of buprenorphine(Bup) on opioids dependence treatment. Method: Rats of dependence on morphine was treated with Bup; the scores of withdrawal symptoms and time spent in morphine-paired box was measured at the 24 hour, 72 hour and on the 8th day in test rates . Result: Bup could inhibit some withdrawal symptoms significantly, but could not change the time spent in the morphine-paired box. Conclusion: Bup can not change conditioned place preference of morphine. Psychological therapy is needed to prevent relapse opioids abuse.
出处
《中国药物依赖性杂志》
CAS
CSCD
2000年第1期21-22,共2页
Chinese Journal of Drug Dependence
关键词
丁丙诺啡
吗啡依赖
戒断综合征
位置偏爱
buprenorphine
morphine dependence
withdrawal symptom
conditioned place preference
