摘要
目的评价腹腔镜及开腹手术治疗浆膜浸润结直肠癌病人的预后。方法回顾性分析2003年6月至2007年6月南方医科大学附属南方医院收治的浆膜浸润结直肠癌病人的临床、病理资料及随访数据。对两组病人生存及复发情况进行比较。结果腹腔镜组和开腹组病人的基线数据及随访时间差异无统计学意义。腹腔镜组总死亡率为20.7%,开腹组为28.9%,两组之间差异无统计学意义(P=0.234);腹腔镜组肿瘤相关死亡率为17.2%,开腹组为26.8%,两组之间差异无统计学意义(P=0.105);腹腔镜组复发率为12.1%,开腹组为26.8%,差异有统计学意义(P=0.024)。生存分析显示腹腔镜组病人累积无复发率高于开腹组(P=0.035),两组病人累积总存活率(P=0.159)及肿瘤相关存活率(P=0.083)差异无统计学意义。结论对于浆膜侵润的结直肠癌,腹腔镜组病人复发率明显低于开腹组,因此可以获得部分优于开腹手术的结果。
Objective To evaluate the prognosis between laparoscopic and open approach in treatment of serosa-invaded colorectal cancer. Methods The clinicopathological and follow-up data of patients with serosa-invaded colorectal cancer in the Nan fang Hospital of Southern Medical University from Jun. 2003 to Jun. 2007 were analyzed retrospectively. Recurrence and survival rates were compared respectively between two groups. Results There were no statistically significant differences of baseline data and follow up period between laparoscopic surgery （LS） and open surgery （OS） groups. No significant differences were observed in overall mortality （20.7 % in LS and 28.9 % in OS, P= 0.234） and cancer-related mortality （17.2% in LS and 26.8 % in OS, P =0.105）. The difference of recurrence rate （12.1% in LS and 26.8 % in OS, P= 0.024） between the two groups was significant. As survival analysis showed, there were no significant differences in cumulative overall survival（P=0.159） and cumulative cancer-related survival（P= 0.083）. The difference of recurrence-free rates between the two groups was significant（P=0.024）. Conclusion The recurrence rate of LS was fewer obviously than OS, sO the laparoseopic surgery can obtain some superior outcomes compared with open surgery for serosa-invaded colorectal cancer.
出处
《中国实用外科杂志》
CSCD
北大核心
2012年第1期88-91,共4页
Chinese Journal of Practical Surgery
关键词
浆膜浸润结直肠癌
腹腔镜手术
开腹手术
预后
serosa-invaded colorectal cancer
laparoscopic surgery
open surgery
prognosis
