摘要
目的：阐明锌离子对学习记忆行为及其相关脑区超微结构的影响，探讨学习记忆的神经机制。方法：通过一次性被动回避反应，并以步入潜伏期的时间为指标，筛选出１０只记忆力低劣的大鼠，建立大鼠记忆力模型。观察其大脑皮质感觉运动区及海马 ＣＡ３区神经元的突触变化。结果：喂锌大鼠电击后 ２４ ｈ的步入潜伏期时间显著延长（Ｐ＜０．０５），两脑区突触后膜致密物质非常显著增厚（Ｐ＜０．０１）。突触界面呈现平直型，正向弯曲型和负向弯曲型三种，以平直型为主，结论；锌离子可增强记忆能力，并影响相关脑区神经元突触发生可塑性变化，突触后膜致密物质厚度与记忆力强弱有相关关系。
To study the effect of Zinc on learning and memory and related brain areas ultrastructure and explore the nervous mechanism of learning and memory. Through one--trial passive avoidance response, ten rats with bad memory were selected according to step--through latency(STL), and a rat memory model was developed. The Synaptic changes of neuron were observed in sensori- motor area of cortex and hippocampal CA3 area. The results were as follows: After given Zinc, the postsynaptic density material of 2 brain areas in experimental group rats became significantly thicker (P< 0. 01 ); 24 hours after electrical shock, STL period was significantly longer (P< 0. 05). The synaptic interface could be positively curved, negatively curved and flat, the flat was the main type. The above results suggest that Zinc can strengthen memory and affect the synapses of neuron in relevant brain areas, causing plastic changes. The thickness of postsynaptic density material is related with the strength of memory.
出处
《解剖学杂志》
CSCD
北大核心
2000年第1期42-48,共7页
Chinese Journal of Anatomy
