摘要
目的:探讨消疲怡神口服液抗应激的作用机理。方法:观察了消疲怡神口服液对强制冷水游泳大鼠模型血清单胺类物质、肾上腺抗坏血酸和下丘脑垂体单胺类递质含量及胸腺指数的影响。结果:消疲怡神口服液可以拮抗应激所致血清多巴胺、5羟色胺含量升高和肾上腺抗坏血酸含量降低,使降低的下丘脑垂体去甲肾上腺素、5羟色胺含量回升,但对胸腺指数无明显影响。结论:消疲怡神口服液的作用机制与其对机体下丘脑—垂体—肾上腺—胸腺轴的调节有关。
To investigate the effect of Xiaopi Yishen (XPYS) oral liquid on the rats under repeated forced cold water swimming (RFCWS) stress. Methods: The changes of serum monoamine, ascorbic acid levels in adrenal gland, monoamine levels in hypothalamus and hypophysis, and thymus index were determined. Results: XPYS lowered the increasing of serum DA, 5 HT, improved the reducing of ascorbic acid in adrenal gland and NE, HVA, 5 HT, 5 HITT in hypothalamus and hypophysis of RFCWS stressed rats. Conclusion: The mechanism of XPYS is in connection with the regulation of hypothalamus pituitary adrenal gland thymus axis.
出处
《中国中西医结合杂志》
CSCD
北大核心
2000年第2期116-119,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金!No .3950 0 1 84
国家中医药管理局!No.95B1 0 9
关键词
消疲怡神口服液
下丘脑
垂体
肾上腺
胸腺轴
应
Xiaopi Yishen oral liquid
repeated forced cold water swimming
hypothalamus pituitary adrenal gland thymus axis
