期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Inhibitory effects of apogossypolone on subcutaneous implants of human LNCaP prostatic carcinoma cells

Apogossypolone对人前列腺癌LNCaP移植瘤的生长抑制作用(英文)
在线阅读 下载PDF
导出
摘要 Objective:The aim of this study was to investigate the inhibitory effect of apogossypolone (ApoG2) on subcutaneous implants of human LNCaP prostatic carcinoma cells, and explore its mechanism. Methods:To establish human LNCaP prostatic carcinoma cell line subcutaneous xenograft models and observe the inhibitory effect of ApoG2 on the tumor model. Immunohistochemistry was employed to observe the expression of Bcl-2, PCNA, CD31, caspase-3 and-8 in tumor tissues. The microvessel density was calculated. Results:ApoG2 could obviously inhibit the growth of subcutaneous prostatic carcinoma implant. ApoG2 decreased the expression of PCNA and CD31, and increased the expression of caspases-3,-8 in tumor tissues. Conclusion:ApoG2 has an inhibitory effect on prostatic carcinoma implants.
作者 Yaozhen Chen Haishan Chen Chen Chen Xiaofeng Huang Shijie Mu Mengyao Zhang Xingbin Hu Qunxing An Xianqing Zhang
机构地区 Department of Blood Transfusion Department of Blood Transfusion Central laboratory Department of Chemistry
出处 《The Chinese-German Journal of Clinical Oncology》 CAS 2012年第1期33-36,共4页 中德临床肿瘤学杂志（英文版）
关键词 apogossypolone （ApoG2） prostate cancer LNCaP human prostatic carcinoma cell line TRANSPLANTATION 前列腺癌细胞 抑制作用 植入 人类 caspase-3 免疫组织化学方法 半胱天冬酶-3 上皮
分类号 Q492.6 [生物学—生理学] TQ245.23 [化学工程—有机化工]
  • 相关文献

参考文献2

二级参考文献26

  • 1Zhang M, Liu H, Guo R, et al. Molecular mechanism of gossypolinduced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. Biochem Pharmacol, 2003 ; 66 : 93 - 103.
  • 2Jarvis WD, Turner AJ, Povirk LF, et al. Induction of apoptotic DNA fragmentation and cell death in HL450 human promyeloeytic leukaemia cells by pharmacological inhibitors of protein kinase C. Cancer Res, 1994; 54:1707-1714.
  • 3Blackstaffe L, Shelley MD, Fish RG. Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines. Melanoma Res, 1997 ; 7 : 364 - 372.
  • 4Mohammad RM, Wang S, Aboukameel A, et al. Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X ( L ) [ (-)-gossypol] against diffuse large cell lymphoma. Mol Cancer Ther, 2005; 4:13 -21.
  • 5Mohammad RM, Wang S, Banerjee S, et al. Nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL, (-)-Gossypol, enhances biological effect of genistein against BxPC-3 human pancreatic cancer cell line. Pancreas, 2005; 31:317-324.
  • 6Xu L, Yang D, Wang S, et al. (-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer. Mol Cancer Ther, 2005; 4:197 -205.
  • 7Ergun MA, Konac E, Erbas D, et al. Apoptosis and nitric oxide release induced by thalidomide, gossypol and dexamethasone in cultured human chronic myelogenous leukemic K-562 cells. Cell Biol Int, 2004 ; 28 : 237 - 242.
  • 8Hou DX, Uto T, Tong X, et al. Involvement of reactive oxygen species-independent mitochondrial pathway in gossypol-induced apoptosis. Arch Biochem Biophys, 2004 ; 428 : 179 - 187.
  • 9Stein RC, Joseph AE, Matlin SA, et al. A preliminary clinical study of gossypol in advanced human cancer. Cancer Chemother Pharma- col, 1992 ; 30 : 480 - 482.
  • 10Bushunow P, Reidenberg MM, Wasenko J, et al. Gossypol treatment of recurrent adult malignant gliomas. J Neurooncal, 1999; 43: 79 - 86.

共引文献17

The Chinese-German Journal of Clinical Oncology
2012年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部