摘要
目的:探讨apogossypolone(ApoG2)对前列腺癌LNCaP细胞系裸鼠皮下移植瘤的生长抑制作用及可能的机制。方法:建立人前列腺癌LNCaP细胞系的裸鼠移植瘤模型,观察ApoG2对皮下移植瘤的生长抑制作用,通过免疫组化方法检测肿瘤组织中PCNA、Bcl-2、CD31、caspase-3及easpase-8的表达,并进行平均微血管密度(MVD)计数。结果:ApoG2可以有效抑制LNCaP移植瘤的生长,ApoG2降低肿瘤组织内PCNA和CD31的表达,增强了caspase-3,8的表达。结论:ApoG2可有效抑制LNCaP移植瘤的生长。
Objective： To investigate the inhibitory effect of apogossypolone（ ApoG2 ） on subcutaneous implants of human LN- CaP prostatic carcinoma cells , and explore its mechanism. Methods： To establish human LNCaP prostatic carcinoma cell line subcutaneous xenograft models and observe the inhibitory effect of ApoG2 on the tumor model. Immunohistochemistry was employed to observe the expression of Bcl- 2, PCNA, CD31, caspase- 3 and- 8 in tumor tissues. The microvessel density was calculated. Results ： ApoG2 could obviously inhibit the growth of subcutaneous prostatic carcinoma implant. ApoG2 decreased the expression of PCNA and CD31, and increased the expression of caspases-3,-8 in tumor tissues. Conclusion： ApoG2 has an inhibitory effect on prostatic carcinoma implants.
出处
《肿瘤预防与治疗》
2011年第3期153-156,共4页
Journal of Cancer Control And Treatment
