摘要
已有文献报道视前区是脑内与镇痛和针刺镇痛有关的核团之一。我们曾观察到视前区注入6-羟基多巴胺,减少内源性儿茶酚胺含量可以加强针刺镇痛作用。
Previous work has shown that activation of catecholamine in the preoptic area is to the disadvantage of acupuncture analgesia. In this work microinjection and push-pull perfusion as well as HPLC-ECD were used to observe the effect of noradrenaline and dopamine in this area on acupuncture analgesia. The results indicated that microinjection of noradrenaline (0.5μg/unilateral) into the preoptic area could attenuate acupuncture analgesia, while dopamine (2μg/unilateral) had no effect on acupuncture analgesia. During acupuncture analgesia, the contents of noradrenaline and MHPG in the perfusate from the preoptic area were markedly decreased, and that of dopamine, however, was not changed significantly. The above results suggest that activating noradrenaline, but not dopamine, exerts antagonistic effect on acupuncture analgesia.
出处
《针刺研究》
CAS
CSCD
1990年第2期117-122,共6页
Acupuncture Research
基金
中国科学院科学基金资助的课题(84)科基金生准字第154号
