摘要
目的：观察深部热疗联合顺铂增敏同步放疗治疗中晚期宫颈癌的疗效及安全性。方法：138例Ⅲ期宫颈癌患者,按就诊顺序随机均分为深部热疗联合顺铂增敏同步放疗组（试验组）和顺铂增敏同步放疗组（对照组）。两组患者均进行根治性放疗;放疗第1 d开始行顺铂化疗,顺铂40 mg/m2,每周1次,共5~6周期。试验组：放化疗方法同对照组,于化疗及腔内放疗当日行盆腹腔深部热疗,每周2次,每次热疗60min,共6周。结果：两组的近期疗效、肿瘤局部控制情况、3年无瘤生存率及局控率间差异有统计学意义（P〈0.05）,但两组3年生存率间差异无统计学意义（P〉0.05）;两组毒副反应比较,差异无统计学意义（P〉0.05）。结论：深部热疗联合顺铂增敏同步放疗可以提高患者近期疗效及3年无瘤生存率、3年局部控制率,且无严重的并发症,是中晚期宫颈癌治疗中的一种安全有效的模式,具有临床推广价值。
Objective： To study the efficacy and safety of deep hyperthermia combined with concurrent radiochemotherapy in the treatment of advanced cervical cancer. Methods：The 138 eases of patient with advanced cervical cancer were randomly divided into experimental and control groups, each of 69 eases. Radical radiation therapy was carried out, then followed by concurrent chemotherapy from the first day of radiotherapy, Administering DDP 40 mg/m^2/week, five tosix cycles totally. The deep hyperthermia with concurrent chemotherapy was given to the experimental group, lasting for 1 hour twice weekly, 6 weeks totally. Results： The experimental group＇s complete remission rate, efficiency rate, local control rate were super than the control group（P 0.05）;There was no significantly different in the 3 year survival rate between the two groups（P 〉0.05）, While the 3 years free survival rate and 3 year local control rate of the experimental group were significantly higher than the control group（P 〈 0.05）. There was no statistical significance in the toxicity between two groups（P 0.05）. Conclusion： Deep hypertherrnia combined with concurrent radiochemotherapy can improve the recent efficacy, had no serious complication. It was a safe and effective mode to treat advanced cervical cancer and had great clinical value.
出处
《内蒙古医学杂志》
2011年第9期1045-1047,共3页
Inner Mongolia Medical Journal
关键词
宫颈癌
同步放化疗
深部热疗
疗效
Cervical cancer
Radiochemotherapy
Deep hyperthermia
Curative effect
