摘要
目的探讨小剂量顺铂CCRT与单纯放射治疗中晚期宫颈癌的疗效和毒副作用。方法 2006~2009年收治的67例经病理确诊的Ⅱb-Ⅳ期宫颈癌患者,随机分为同步放化疗组35例和单纯放疗组32例,同步放化疗组给予顺铂400 mg/（次.w）行放疗增敏,两组同样放疗剂量。比较两组的治疗效果和不良反应。结果 CCRT组完全缓解率77.1%,单纯放疗组43.8%;总有效率：CCRT组94.3%,单纯放疗组71.9%;3年生存率：CCRT组88.6%,单纯放疗组68.8%,两组差异有统计学意义（P〈0.05）。结论小剂量顺铂增敏CCRT治疗晚期宫颈癌可显著提高有效率和生存率,急性不良反应与单纯放疗组相比无明显增加。
Objective To investigate the therapeutic effects and side effects of concurrent chemoradiation therapy（CCRT） with low-dose cisplatin and pelvic radiotherapy alone on stage Ⅱb-Ⅳ cervical cancer.Methods From 2006 to 2009,67 patients with advanced cervical cancer at stages Ⅱb-Ⅳ confirmed by pathological examination were randomly divided into CCRT group（35 cases） and radiotherapy group（32 cases）.Both groups were given the same radiation dose of 60Co during pelvic radiotherapy.Those in CCRT group was also treated with weekly 40 mg cisplatin chemotherapy.Therapeutic effects and adverse reactions were compared each other after treatment.Results Complete response rate in CCRT group and in radiotherapy group was 77.1% and 43.8%,respectively.The total effective rate was 94.3% in CCRT group and 71.9% in radiotherapy group.3-year survival rate was 88.6% and 68.8%,respectively.There were significant differences in effective rate and 3-year survival rate between the two groups（P0.05）.Nevertheless,side effects such as rectal and bladder complications and bone marrow depression between them had no significant differences（P0.05）.Conclusion CCRT with low-dose cisplatin in the treatment of cervical cancer at middle and advanced stage can significantly improve the effective rate and survival rate without increasing acute adverse reactions.
出处
《西南国防医药》
CAS
2011年第6期610-613,共4页
Medical Journal of National Defending Forces in Southwest China
