摘要
目的检测儿童横纹肌肉瘤组织中CD117蛋白的表达，并分析其临床病理特点，探讨CD117在儿童横纹肌肉瘤生物靶向治疗中的意义。方法观察29例经手术切除的儿童横纹肌肉瘤石蜡标本的病理形态学特征，采用免疫组化Envision法检测其中CD117蛋白的表达，结合临床、病史，分析其与肿瘤分型及分期的关系。结果29例标本中，10例CD117蛋白检测阳性，阳性表达率34．48％；其中胚胎型横纹肌肉瘤24例，7例CD117表达阳性，阳性表达率29．17％；腺泡型横纹肌肉瘤5例，3例CD117表达阳性，阳性表达率60％。统计分析表明CD117阳性表达率在不同组织学类型间、不同临床分期间比较，差异无统计学意义（P〉0．05）。结论CD117蛋白在胚胎型和腺泡型儿童横纹肌肉瘤组织中均有表达，靶向治疗在CD117表达阳性的儿童横纹肌肉瘤患儿中具有潜在应用价值。
Objective To detect the expression of CD117, and to investigate the significance of this marker in pathologic diagnosis and targeted therapy for children＇ s rhabdomyosarcoma. Methods After the morphological observation,the expression of CD117 in 29 eases of rhabdomyosareoma were investigated by immunohistochemical staining. The relationship between the expression of CD117 and grouping or stage of the tumor was analyzed. Results Ten cases were tested the expression of CD117 and the expression rate was 34. 48%. There were 24cases of embryonal rhabdomyosarcoma with 7 CD117 positive （29.17%） and 5 cases of gland alveolus rhabdomyosarcoma with 3 CD117 positive （60%）. There was no significant difference among the expression of CD117 in different grouping and stage of the tumor. Conclusion CD117 is expressed both in embryonal rhabdomyosarcoma and gland alveolus rhabdomyosareoma. Targeted therapy of children＇ s rbabdomyosarcoma may be useful,especially when the expression of CD117 is positive.
出处
《临床小儿外科杂志》
CAS
2011年第6期427-429,共3页
Journal of Clinical Pediatric Surgery
