摘要
目的探讨胃间质瘤(GISTs)临床病理学特征与预后的相关性。方法回顾性对36例胃GISTs的临床病理及随访资料进行分析,并采用免疫组织化学方法(SP法)检测CD117,CD34,SMA(平滑肌肌动蛋白),S-100蛋白及Ki-67蛋白等抗体在肿瘤中的表达.结果很低度、低度、中度及高度侵袭危险性病例数分别为4例、18例、10例及4例;免疫组织化学显示很低、低度、中度及高度侵袭危险组中的ki-67标记指数分别为(6.2±2.2)%(、8.6±3.5)%、(18.0±7.6)%及(25.0±8.6)%,标记指数相互比较均存在着非常显著性差异(P<0.01),其它抗体在各组中的表达无明显差异。随访的28例病例中6例出现复发和转移,且均为中、高度侵袭危险病例。结论胃GISTs临床病理的分级及Ki-67标记指数的测定有助于临床预后的判断。
Objective To investigate the correlation of clinicopathologic features and prognosis of Gastrointestinal stromal tumours （GISTs）. Methods The clinicopathologic features and data collected during the follow-up visit of 36 cases of GISTs were retrospectively reviewed. The antibodies of CDll7, CD34,SMA, S-100 and Ki-67 were detected by immunohistochemical method. Resuits According to the Fletcher＇s scheme,the cases were subdivided into those of very low risk of infiltration（4 cases）,low risk（18 cases） ,medium risk（10 cases） and high risk（4 cases）. The Ki-67 labeling index（KLI ） in very low risk, low risk, medium risk and high risk groups of GISTs was （6.2 ± 2.2） %, （8.6 ± 3.5） %, （ 18.0 ± 7.6） % and （25.0 ± 8.6） % respectively, showing a significant difference between four groups（P 〈 0.01）. No significant difference was observed in other markers. At the follow-up visit, 6 of 28 cases underwent relapse and metastasis. All the six cases had medium risk and high risk of infiltration. Conclusion The clinicopathologic grade and Ki-67 labeling index of GISTs may be useful for prognosis.
出处
《实用癌症杂志》
2005年第5期510-513,共4页
The Practical Journal of Cancer
关键词
胃间质瘤
免疫组织化学
CD117蛋白
KI-67蛋白
Gastrointestinal stromal tumors （GISTs）
Immunohistochemistry
CD117 protein
Ki-67 protein
