摘要
目前缺血性心脏病的发病率位于原发性心脏病之首,其中心肌缺血再灌注损伤约占50%以上。因此,开发治疗心肌缺血再灌注损伤的多靶点药物对防治心脏疾病具有重大价值和意义。研究MIRI的分子机制并开发针对各种靶点的MIRI抑制剂,以此调控多种信号通路,为进一步阐明MIRI分子机制及研发相关药物提供了新的思路。
At the present time,the incidence of ischemic heart disease has took the premier place of Primary heart disease.Among the rest,myocardial ischemia-reperfusion injury which accounts for about over 50%.for this reason,The development of the multi-target drugs to repair myocardial ischemia-reperfusion injury is of great value and significance on prevention and treatment of heart disease.Investigate the molecular mechanism of MIRI and develop inhibitors which against various targets involve with MIRI to regulate multiple signaling pathways,It provides a new idea for further elucidate the molecular mechanism of MIRI and develop related drugs.
出处
《中国医药科学》
2012年第1期30-32,57,共4页
China Medicine And Pharmacy
基金
国家自然科学基金资助项目(81173503)
关键词
心肌缺血再灌注损伤
信号通路
靶点
抑制剂
Myocardial ischemia-reperfusion injury； Signal passage； Target spot； Inhibitor；
