摘要
目的观察氧气吸入联合放松训练治疗广泛性焦虑障碍（GAD）的疗效。方法将188例GAD患者随机分为治疗组及对照组，2组患者均常规给予帕罗西汀治疗，治疗组在此基础上辅以氧气吸人及放松训练，对照组则视病情辅以苯二氮卓类药物口服。于治疗前、治疗4周后分别采用汉密尔顿焦虑量表（HAMA）、临床疗效总评量表（CGI）中的疗效总评部分（GI）及治疗意外症状量表（TESS）评价2组患者l临床疗效及不良反应情况，并比较治疗前、后2组患者呼吸、心率及血压等生理指标变化情况。结果2组患者HAMA评分均于治疗第2周明显下降（P〈0．05），第3周、第4周时亦显著低于治疗前水平（P〈0．05）；治疗组HAMA评分在治疗第1周、第2周时较对照组显著降低，治疗第3周、第4周时组间差异无统计学意义（P〉0．05）；2组患者GI评分均较治疗前明显降低（P〈0．05），并且以治疗组的降低幅度相对较显著（P〈0．05）；2组患者不良反应情况均较轻微，其TESS评分组间差异无统计学意义（P〉0．05）。结论在常规药物治疗基础上辅以氧气吸人及放松训练，可迅速改善GAD患者焦虑症状、提高疗效，并且治疗过程中无明显不良反应，患者治疗依从性较好。
Objective To observe the therapeutic effects of oxygen inhalation combined with relaxation training on patients ,with generalized anxiety disorder （GAD）. Methods A total of 188 GAD patients were divided into the study group and the control group randomly. The two groups were treated with conventional antianxiety drugs （paroxetine） , in addition to conventional medical therapy. The study group was aided with oxygen inhalation and relaxation training, the control group was given henzodiazepine. The scores of Hamilton anxiety rating scale （HAMA） , global improvement（GI） [ a part of clinical global impression （CGI）], and treatment emergent symptom scale （TESS） were used to evaluate clinical effects and adverse reactions before and after 4-week treatment. The indexes of breathing, heart rate and blood pressure were evaluated before and after treatment. Results The scores of HAMA scale and GI in the two groups were significantly different after treatment（ P 〈 0.05 ） , and the study group changed significantly（ P 〈 0.05 or P 〈 0.01 ）. The adverse reactions of the two groups were slight, there was no significant difference of TESS before and after treatment （ P 〉 0. 05 ）. There was no significant difference in terms of breathing, heart rate and blood pressure between the two groups before treatment（ P 〉 0.05 ） , but were all lower after treatment the study group changed more apparently and significantly（ P 〈 0.01 ）. Conclusions Based on conventional drugs treatment oxygen inhalation combined with relaxation training could improve anxiety and somatization rapidly, there was no obvious adverse reaction and the patients compliance was good, so the treatment was worth to use in clinic.
出处
《中华物理医学与康复杂志》
CSCD
北大核心
2012年第1期41-44,共4页
Chinese Journal of Physical Medicine and Rehabilitation
关键词
氧气吸入
放松训练
广泛性焦虑障碍
Oxygen inhalation
Relaxation training
Generalized anxiety disorder
