7Graser RT,Dilorenson TP,Wang F.Identification of a CD8 T cell that canindependently mediate autoimmune diabetes development in the completeabsence of CD4 T cell helper functions[J].J Immunol,2000;164(7):3913-8.
3Alyanakian MA, You S, Damotte D, et al. Diversity of regulato-ry CD4+ T cells controlling distinct organ-specific autoimmune diseases [J]. Proc Nad Acad Sci USA,2003,100(26) :15806-15811.
4Carlsson A,Sundkvist G, Groop L,et al. Insulin and glueagons secretion in patients with slowly progressing autoimmune diabetes (LADA) [ J]. J Clin Endocrinol Metab,2000,85( 1 ) :76-80.
5Tanaka H, Demeure CE, Rubio M, et al. Human monocyte derived dendritic cells induce nativeT celldifferentiation intoThelper cell type2 (Th2) or Th1 /Th2 effeclors: role of stimulator/responder ratio[J]. J Exp Med,2000,192(3) :405-412.
6Shimada A, Kodama K, Morimoto J,et al. Detection of GAD-reactive CD4^+ cells in so-called “type 1 B” diabetes[ J ]. Ann N Y Acad Sci, 2003,1005(5) :378-386.
7Lee S J, Hwang HS, Kim BN, et al. Changes in serum adenosine deaminase activity during normal pregnancy [J]. J Korean Med Sei, 2007, 22(4): 718-721.
8Kurtul N, Pence S, Akarsu E, et al. Adenosine deaminase activity in the serum of type 2 diabetes patients[ J]. Acta Medica (Hradec Kralove), 2004, 47(1): 33-35.
9Mc Garry J D.Bantinglecture2001:Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes[J].Diabetes,2002;51(1):17-18.
10EI-Assaad W,Buteau J,Peyot M L et al.Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death[J].Endocrinology,2003;144(9):4154-4163.
2Kuldeep Sharma,Gopal Pawar,Swetha Yadam,Sanjeev Giri,Sriram Rajagopal,Ramesh Mullangi.LC‐MS/MS‐ESI method for simultaneous quantitation of metformin and repaglinidie in rat plasma and its application to pharmacokinetic study in rats[J]. Biomed. Chromatogr. . 2012 (3)
3Cetrone M,Mele A,Tricarico D.Effects of the antidiabetic drugs on the age-related atrophy and sarcopenia associated with diabetes typeⅡ. Curr Diabetes Rev . 2014
4Ahren B.Are sulfonylureas less desirable than DPP-4 inhibitors as on tometformin in the treatment of type 2 diabetes[J].Curr Diab Rep, 2011,11(2): 83-90.
6EIDER D A,HERBERS P M,WEIS T,et al. ~-cell dysfunction in adolescents and adults with newly diagnosed type 2 diabetes mellitus[J]. J Pediatr,2012,160(6) :904-910.
7VAN RAALTE D H, DIAMANT M.Glucolipotoxicity and beta cells in type2 diabetes mellitus:target for durable therapy [J].Diabetes Res Clin Pract, 2011,93 (11 ) : S37-S46.
8Airin C.R. Simon,Frits Holleman,Wouter T.Gude,et al.Safetyand usability evaluation of a web-based insulin self-titrationsystem for patients with type 2 diabetes mellitus [J].Artificialintelligence in medicine,2013,59(1):23-31.