摘要
目的明确维生素D(Vit D)摄入是否与儿童急性下呼吸道感染(ALRI)相关。方法比较因毛细支气管炎或肺炎入院的5岁以下儿童和非配对、无呼吸道感染的同龄对照组儿童之间Vit D摄入的差别。197例儿童的看护人完成了问卷调查,内容包括人口统计变量、ALRI危险因素和饮食。评估ALRI与Vit D摄入及其他危险因素的相关性。结果 ALRI组儿童的平均Vit D摄入为每日48 IU/kg,对照组为每日60 IU/kg。当控制年龄、民族、社会经济地位、北部地区居住、母乳喂养、免疫接种和接触吸烟等因素时,Vit D每日摄入<80 IU/kg的儿童患ALRI的可能性比每日摄入≥80 IU/kg的儿童高4倍(OR=4.9;95%CI:1.5～16.4)。结论为了避免罹患ALRI等疾病,5岁以下儿童可能需要摄入比现在推荐量更高的Vit D剂量。因毛细支气管炎和肺炎是年幼儿童住院的最常见原因,增加Vit D的补充可能有重要的公共卫生保健意义。
Objective To determine if vitamin D intake is associated with acute lower respiratory infections（ALRI） in children.Methods The vitamin D intakes of children younger than 5 years of age admitted to hospital with either bronchiolitis or pneumonia were compared to an unmatched control group of the same age without respiratory infection.Caregivers of 197 children completed a questionnaire collecting information on demographic variables,ALRI risk factors and diet.Associations of ALRI with vitamin D intake and other ALRI risk factors were determined.Results The mean vitamin D intake of children with ALRI was 48 IU/kg/d compared to 60 IU/kg/d in the control group.When controlling for age,ethnicity,socio-economic status,northern residence,breastfeeding,immunizations and smoking contact,children with a vitamin D intake of less than 80 IU/kg/d were greater than 4 times more likely to have ALRI compared to children with a vitamin D intake exceeding 80 IU/kg/d（OR=4.9;95%CI： 1.5~16.4）.Conclusions A higher vitamin D intake than currently recommended might be needed to offer protection against diseases such as ALRI.Increased vitamin D supplementation could have important public health consequences,as bronchiolitis and pneumonia are the most common reasons for hospitalization in young children.
出处
《中国当代儿科杂志》
CAS
CSCD
北大核心
2012年第1期1-6,共6页
Chinese Journal of Contemporary Pediatrics
