摘要
目的:观察温肾养血颗粒对卵泡发育的影响,初步探讨温肾养血颗粒调控卵泡发育的机理。方法:选取60例卵泡发育不良性(follicular maldevelopment,FM)不孕症肾虚血瘀型患者,按随机数字表法分为中药组、西药组,每组30例,分别给予温肾养血颗粒(柴胡、泽兰、益母草、牛膝、淫羊藿、菟丝子、枸杞子等)、枸橼酸氯米芬,共观察3个月经周期。检测患者治疗前后血清黄体生成素(LH)、卵泡刺激素(FSH)、雌激素(E2)、抑制素B(inhibin B,INHB)、激活素A(activin A,ACTA)、卵泡抑素(fol-listatin,FS)水平;监测卵泡发育及基础体温。结果:两组临床疗效比较,差异均无统计学意义(P>0.05)。中药组在中医证候疗效、排卵率和排卵日子宫内膜厚度方面明显优于西药组,差异均有统计学意义(P<0.05)。与本组治疗前比较,中药组和西药组治疗后第1个月经周期第3天血清E2、FSH、LH、INHB、ACTA及FS比较无统计学差异(P>0.05),第10天血清INHB及FS升高,ACTA降低,差异有统计学意义(P<0.05)。结论:温肾养血颗粒可以改善FM患者的中医证候,调控卵泡发育,其作用可能是通过调节FM患者下丘脑-垂体-卵巢系统和卵巢局部因子INHB、ACTA、FSH的表达的完成。
Objective：To observe the influence of Wenshen Yangxue Granule on the follicular development and preliminarily discuss the mechanism of Wenshen Yangxue Granule in regulating and controlling the follicular development.Methods：60 patients with follicular maldevelopment sterility of kidney deficiency and blood stasis type were randomly divided into Chinese medicine group and western medicine group according to random number table method with 30 cases in each,who were respectively treated with Wenshen Yangxue Granule（Bupleurum,Zeeland,Motherwort,Achyranthes,Epimedium,Dodder,wolfberry fruit,etc.） and Clomifene Citrate and observed for three menstruation cycles.The luteinizing hormone（LH）,follicle-stimulating hormone（FSH）,estradiol（E2）,INHB,ACTA,and FS serum levels of the two groups were tested and the follicular development and the basic body temperature were monitored.Results：The difference of the clinical efficacy of both groups did not reach statistical significance（P〉0.05）.The Chinese medicine group was significantly superior to the western medicine group in symptoms of TCM,ovulation rate and the endometrium thickness on the day of ovulation,and there was statistical significance（P〈0.05）.Comparison in their own group before the treatment showed E2,FSH,LH,INHB,ACTA and FS serum levels of both groups had no statistical significance on the third day after the first menstruation cycle treatment（P〉0.05）.The INHB and FS serum levels of the two groups on the 10th day after the first menstruation cycle treatment were higher than those before the treatment,but ACTA was lower,and there was statistical significance（P〈0.05）.Conclusion：Wenshen Yangxue Granule can improve the TCM symptoms of FM patients and regulate the follicular development through regulating the hypothalamus pituitary ovary axis and the expression of ovary local factors such as INHB,ACTA and FS.
出处
《中医学报》
CAS
2012年第2期233-236,共4页
Acta Chinese Medicine
基金
北京市卫生局
北京市中医管理局青年科研资助项目(编号:QN-2008-7)
