摘要
目的观察阿魏酸钠注射液肾囊注射对肾性蛋白尿患者24 h尿蛋白定量、内生肌酐清除率(Ccr)、血浆内皮素-1(ET-1)的影响及临床疗效。方法将105例原发性肾小球疾病患者随机分为3组,3组均予基础治疗。对照1组35例加阿魏酸钠注射液静脉滴注,每日1次;治疗组35例在对照1组的基础上加阿魏酸钠注射液肾囊注射,每周2次;对照2组在基础治疗的基础上加香丹注射液静脉滴注,每日1次。3组均5周为1个疗程,治疗1个疗程。检测3组治疗前后24 h尿蛋白定量、Ccr及ET-1变化情况,统计临床疗效及不良反应。结果 3组治疗后24 h尿蛋白定量与本组治疗前比较均明显下降(P<0.05)。治疗组治疗后24 h尿蛋白定量及ET-1与对照1组治疗后比较差异有统计学意义(P<0.05)。与对照2组治疗后比较,治疗组、对照1组治疗后24 h尿蛋白定量及ET-1明显下降(P<0.05),Ccr上升(P<0.05)。治疗组及对照1组总有效率高于对照2组(P<0.05),且治疗组与对照1组比较差异有统计学意义(P<0.05)。3组均无不良反应。结论阿魏酸钠注射液可用于治疗原发性肾小球疾病所致蛋白尿,疗效显著,在降低尿蛋白的同时,可拮抗血浆高ET-1水平对血管内皮的损害,保护肾功能,采用肾囊注射的方法给药可提高疗效,且安全性较高。
Objective To observe the effect of renal intracapsular injection of sodium ferulate injection on the treatment of renal proteinuria. Methods 105 cases of primary glomerular disease were randomly divided into three groups. Patients in three groups were treated by conventional therapy. And control group one （ n = 35 ） re- ceived intravenous injection of sodium ferulate injection, once a day. Treatment group （ n = 35 ） received renal intra- capsular injection of sodium ferulate injection on the basis of control one group＇s therapy, twice a week. Control group two （ n = 35 ） was treated by Xiangdan intravenous injection, once a day. A course of treatment was five weeks in three groups. The changes of 24 h urinary protein, endogenous creatinine clearance rate （Ccr） and plasma endo- thelin - 1 （ ET - 1 ） were detected before and after treatment, clinical efficacy and adverse reactions were analyzed. Results 24 h urinary protein after treatment was decreased as compared with that before treatment in three groups （ P 〈 0.05）. There was significant difference between treatment group and control group one on 24 h urinary protein and ET - 1 （ P 〈 0.05 ）. 24 h urinary protein and ET - 1 in treatment group and control group one were obviously decreased as compared with those in control group two after treatment （ P 〈 0.05 ）. Ccr was increased in treatment group and control group one （ P 〈 0.05 ）. There was significant difference between treatment group and control group one on Ccr （ P 〈 0.05 ）. There was no adverse reaction in three groups. Conclusion Sodium ferulate injection can be used to treat primary glomerular disease -induced proteinuria, has a significant effect in reducing urinary protein at the same time, could antagonize high levels of ET - 1 - induced endothelial damage and protect renal function, the method of renal intracapsular injection of sodium ferulate injection can improve the efficacy and is higher safety.
出处
《河北中医》
2011年第11期1695-1697,共3页
Hebei Journal of Traditional Chinese Medicine
关键词
阿魏酸
注射剂
蛋白尿
注射
病灶内
肾小球肾炎
IGA
Ferulaie acid
Injection
Albuminufia
Inject
Focus of infection
Glomerular nephritis
IGA
