摘要
对黄体时期VEGF依赖性血管生成的分子机制研究,将有助于我们开发新的策略用于治疗黄体相关的不孕症,以及改善动物的繁殖性能。论文对VEGF在家畜黄体血管生成过程中的调控作用进行综述,旨在为临床研究及畜牧生产提供理论依据及参考资料。
Angiogenesis is a process of vascular growth which is mainly limited to the reproductive system in healthy adult animals. In mammalian, the corpus luteum is a site of intense angiogenesis. Within a short period of the corpus luteum, the angiogenesis is followed either by controlled regression of the micro- vascular tree in the non-fertile cycle, or maintenance and stabilisation of the new vasculature in a conceptu- al cycle. Therefore, the corpus luteum is a unique model system in which the cellular and molecular regula- tion of angiogenesis can be studied. The development of new blood vessels in the ovarian corpus luteum is essential for corpus luteum formation to guarantee the necessary supply of nutrients and hormones. At present, the study of the molecular mechanism indicated vascular endothelial growth factor has a major role in the corpus luteum, since significantly inhibitory effects on luteal angiogenesis and function are observed when its action was blocked by antagonists at specific stages of the luteal phase in vivo. Investigations of the mechanisms of vascular endothelial growth factor-dependent angiogenesis in mammalian corpus luteum will provide insights into new strategies in treatment of luteal-based infertility and methods of improving animal reproduction. Based on our previous researches, we reviewed the effect of vascular endothelial growth factor on luteal angiogenesis in livestock, in order to provide some important references for clinic researches and animal husbandry production.
出处
《家畜生态学报》
2011年第6期124-128,共5页
Journal of Domestic Animal Ecology
基金
国家自然科学基金(31101032
31040084)
福建师范大学高层次人才引进项目(2010MIN114)
国家级生物学实验教学示范中心创新性研究计划项目(2011LS017)
福建省自然科学基金(2011J01144)
福建省教育厅科技项目(AJ11041)
关键词
VEGF
黄体
血管生成
Vascular Endothelial Growth Factor
corpus luteum
angiogenesis
